Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shengmin Sang | - |
dc.contributor.author | Joshua D. Lambert | - |
dc.contributor.author | Shiying Tian | - |
dc.contributor.author | Jungil Hong | - |
dc.contributor.author | Zhe Hou | - |
dc.contributor.author | Ryu, Jae Ha | - |
dc.contributor.author | Ruth E. Stark | - |
dc.contributor.author | Robert T. Rosen | - |
dc.contributor.author | Mou-Tuan Huang | - |
dc.contributor.author | Chung S. Yanga | - |
dc.contributor.author | Chi-Tang Hob | - |
dc.date.accessioned | 2022-04-19T11:46:45Z | - |
dc.date.available | 2022-04-19T11:46:45Z | - |
dc.date.issued | 2004-01 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.issn | 1464-3391 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148987 | - |
dc.description.abstract | Derivatives based on a benzotropolone skeleton (9–26) have been prepared by the enzymatic coupling (horseradish peroxidase/H2O2) of selected pairs of compounds (1–8), one with a vic-trihydroxyphenyl moiety, and the other with an ortho-dihydroxyphenyl structure. Some of these compounds have been found to inhibit TPA-induced mice ear edema, nitric oxide (NO) synthesis, and arachidonic acid release by LPS-stimulated RAW 264.7 cells. Their cytotoxic activites against KYSE 150 and 510 human esophageal squamous cell carcinoma and HT 29 human colon cancer cells were also evaluated. Derivatives based on a benzotropolone skeleton (9–26) have been prepared by the enzymatic coupling (horseradish peroxidase/H2O2) of selected pairs of compounds (1–8), one with a vic-trihydroxyphenyl moiety, and the other with an ortho-dihydroxyphenyl structure. Some of these compounds have been found to inhibit TPA-induced mice ear edema, nitric oxide (NO) synthesis, and arachidonic acid release by LPS-stimulated RAW 264.7 cells. Their cytotoxic activities against KYSE 150 and 510 human esophageal squamous cell carcinoma and HT 29 human colon cancer cells were also evaluated. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier | - |
dc.title | Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.bmc.2003.10.024 | - |
dc.identifier.scopusid | 2-s2.0-0347320708 | - |
dc.identifier.wosid | 000188394700014 | - |
dc.identifier.bibliographicCitation | Bioorganic & medicinal chemistry, v.12, no.2, pp 459 - 467 | - |
dc.citation.title | Bioorganic & medicinal chemistry | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 459 | - |
dc.citation.endPage | 467 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0968089603007119?via%3Dihub | - |
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