Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[18F]Fluoropropyl)-6-nitroquipazine
DC Field | Value | Language |
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dc.contributor.author | Lee B.S. | - |
dc.contributor.author | Chu S. | - |
dc.contributor.author | Lee K.C. | - |
dc.contributor.author | Lee B.-S. | - |
dc.contributor.author | Chi D.Y. | - |
dc.contributor.author | Choe Y.S. | - |
dc.contributor.author | Kim S.E. | - |
dc.contributor.author | Song Y.S. | - |
dc.contributor.author | Jin C. | - |
dc.date.accessioned | 2022-04-19T12:03:00Z | - |
dc.date.available | 2022-04-19T12:03:00Z | - |
dc.date.issued | 2003-11 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.issn | 1464-3391 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149072 | - |
dc.description.abstract | 3-(3-[F-18]Fluoropropyl)-6-nitroquipazine ([F-18]FPNQ) as a 5-HT transporter imaging agents was designed, synthesized, and evaluated. FPNQ was selected due to its potent in vitro biological activity (K-i = 0.32 nM) in rat brain cortical membranes. The F-18-labeled FPNQ was prepared by reaction of the propyl mesylate as a precursor with tetra-n-butylammonium [F-18]fluoride generated under NCA conditions. The precursor mesylate was synthesized from commercially available hydrocarbostyril in nine steps in 21% overall yield. The specific activity of the [F-18]FPNQ determined by radioreceptor assay was 27.0 GBq/mumol. Tissue distribution studies in mice showed the highest uptake in the frontal cortex (5.79 %ID/g) at 60 min post-injection. (C) 2003 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[18F]Fluoropropyl)-6-nitroquipazine | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bmc.2003.09.009 | - |
dc.identifier.scopusid | 2-s2.0-0242298240 | - |
dc.identifier.wosid | 000186614400011 | - |
dc.identifier.bibliographicCitation | Bioorganic and Medicinal Chemistry, v.11, no.23, pp 4949 - 4958 | - |
dc.citation.title | Bioorganic and Medicinal Chemistry | - |
dc.citation.volume | 11 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 4949 | - |
dc.citation.endPage | 4958 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0968089603006199?via%3Dihub | - |
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