ISG15, not just another ubiquitin-like protein.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Keun Il | - |
dc.contributor.author | Dong-Er Zhang | - |
dc.date.accessioned | 2022-04-19T12:03:44Z | - |
dc.date.available | 2022-04-19T12:03:44Z | - |
dc.date.issued | 2003-08 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149112 | - |
dc.description.abstract | ISG15 is a ubiquitin-like protein containing two ubiquitin homology domains and becomes conjugated to a variety of proteins when cells are treated with type I interferon or lipopolysaccharide. Although ISG15 shares several common properties with those of other ubiquitin-like molecules, it is a unique member, whose expression and conjugation to target proteins are tightly regulated by specific signaling pathways, indicating it may be associated with specialized functions in innate immune system. Loss of UBP43 (USP18), a protease that specifically removes ISG15 from ISG15-modified proteins, in mice leads to decreased life span, brain cell injury, and hypersensitivity to interferon stimulation. In UBP43 deficient cells, interferon induces a prolonged Stat1 tyrosine phosphorylation and DNA binding, which result in a prolonged and enhanced activation of interferon-stimulated | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press | - |
dc.title | ISG15, not just another ubiquitin-like protein. | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/s0006-291x(03)01216-6 | - |
dc.identifier.scopusid | 2-s2.0-0041670804 | - |
dc.identifier.wosid | 000184509700001 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, v.307, no.3, pp 431 - 434 | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.volume | 307 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 431 | - |
dc.citation.endPage | 434 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X03012166?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.