Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines
DC Field | Value | Language |
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dc.contributor.author | Jeong, HW | - |
dc.contributor.author | Lee, HJ | - |
dc.contributor.author | Kho, YH | - |
dc.contributor.author | Son, KH | - |
dc.contributor.author | Han, MY | - |
dc.contributor.author | Lim, JS | - |
dc.contributor.author | Lee, MY | - |
dc.contributor.author | Han, DC | - |
dc.contributor.author | Ha, JH | - |
dc.contributor.author | Kwon, BM | - |
dc.date.accessioned | 2022-04-19T12:23:06Z | - |
dc.date.available | 2022-04-19T12:23:06Z | - |
dc.date.issued | 2002-10 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.issn | 1464-3391 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149409 | - |
dc.description.abstract | Sesquicillin, isolated from fungal fermentation broth, strongly induced G1 phase arrest in human breast cancer cells. During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21(Waf1/CiP1), was increased in a time-dependent manner in a breast cancer cell MCF-7. Interestingly, the G1 phase arrest induced by sesquicillin also occurred independently of the tumor suppressor protein, p53. Sesquicillin inhibits the proliferation of MCF-7 via G1 phase arrest in association with the induction of CDK inhibitor protein, p21(waf1/CiP1), and the reduction of G1 phase related-cyclin proteins. (C) 2002 Elsevier Science Ltd. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/S0968-0896(02)00225-0 | - |
dc.identifier.scopusid | 2-s2.0-0036335794 | - |
dc.identifier.wosid | 000177834100004 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY, v.10, no.10, pp 3129 - 3134 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.citation.volume | 10 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 3129 | - |
dc.citation.endPage | 3134 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0968089602002250?via%3Dihub | - |
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