Genistein이 햄스터 난소세포의 항산화효소활성과 발현에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김민혜 | - |
dc.contributor.author | 김안근 | - |
dc.date.available | 2021-02-22T15:16:52Z | - |
dc.date.issued | 2007-02 | - |
dc.identifier.issn | 0377-9556 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14959 | - |
dc.description.abstract | Reactive oxygen species (ROS) are produced in the metabolic process of oxygen in cells. The superoxide dis-oxidative stress. Genistein is one of the isoflavonoids, and its role in controlling cellular oxidative stress is presently theactive issue at question. In this study, we analyzed genistein-induced survival rates of the CHO-K1 cells, activities of anti-oxidant enzymes, ROS levels, and expression levels of antioxidant enzyme genes in order to investigate the effect ofgenistein on celular ROS production and antioxidative systems in CHO-K1 cels. As results, the survival rate of cels wasdecreased as the dose of genistein increases (12.5~200M). Genistein increased cellular ROS levels, while it reduced totalSOD activities and the expression of CuZnSOD. In conclusion, we suggest that genistein may induce oxidative stress viadown-regulation of SOD.Keywords . genistein, reactive oxygen species, antioxidant enzyme activity, antioxidant enzyme expression.... .... .. , .. .. .... .... .. | - |
dc.format.extent | 8 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한약학회 | - |
dc.title | Genistein이 햄스터 난소세포의 항산화효소활성과 발현에 미치는 영향 | - |
dc.title.alternative | Effect of Genistein on Activity and Expression of Antioxidant Enzyme in Hamster ovary cells | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | 약 학 회 지, v.51, no.1, pp 75 - 82 | - |
dc.citation.title | 약 학 회 지 | - |
dc.citation.volume | 51 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 75 | - |
dc.citation.endPage | 82 | - |
dc.identifier.kciid | ART001054851 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | genistein | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | antioxidant enzyme activity | - |
dc.subject.keywordAuthor | antioxidant enzyme expression | - |
dc.identifier.url | https://scholar.kyobobook.co.kr/article/detail/4010024046016 | - |
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