Mechanism for the differentiation of EoL-1 cells into eosinophils by histone deacetylase inhibitors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kaneko, Motoko | - |
dc.contributor.author | Ishihara, Kenji | - |
dc.contributor.author | Takahashi, Aki | - |
dc.contributor.author | Hong, JangJa | - |
dc.contributor.author | Hirasawa, Noriyasu | - |
dc.contributor.author | Zee, OkPyo | - |
dc.contributor.author | Ohuchi, Kazuo | - |
dc.date.available | 2021-02-22T15:17:19Z | - |
dc.date.issued | 2007-06 | - |
dc.identifier.issn | 1018-2438 | - |
dc.identifier.issn | 1423-0097 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14992 | - |
dc.description.abstract | Background: EoL-1 cells have a FIP1L1-PDGFRA fusion gene which causes the transformation of eosinophilic precursor cells into leukemia cells. Recently, we suggested that the induction of differentiation of EoL-1 cells into eosinophils by the HDAC inhibitors apicidin and n-butyrate is due to the continuous inhibition of HDACs. However, neither apicidin nor n-butyrate inhibited the expression of FIP1L1-PDGFRA mRNA, although both these inhibitors suppressed cell proliferation. Therefore, in this study, we analyzed whether the levels of FIP1L1-PDGFR alpha protein and phosphorylated-Stat5 involved in the signaling for the proliferation of EoL-1 cells are attenuated by HDAC inhibitors. Methods: EoL-1 cells were incubated in the presence of apicidin, TSA or n-butyrate. FIP1L1-PDGFR alpha and phosphorylated-Stat5 were detected by Western blotting. Results: Treatment of EoL-1 cells with apicidin at 100 nM or n-butyrate at 500 M decreased the levels of FIP1L1-PDGFR alpha protein and phosphorylated-Stat5, while that with trichostatin A at 30 nM did not. Conclusions: The decrease in the level of FIP1L1-PDGFR alpha protein caused by apicidin and n-butyrate might be one of the mechanisms by which EoL-1 cells are induced to differentiate into eosinophils by these HDAC inhibitors. Copyright (C) 2007 S. Karger AG, Basel. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | Mechanism for the differentiation of EoL-1 cells into eosinophils by histone deacetylase inhibitors | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.1159/000101401 | - |
dc.identifier.scopusid | 2-s2.0-34249797291 | - |
dc.identifier.wosid | 000247527500005 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, v.143, pp 28 - 32 | - |
dc.citation.title | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | - |
dc.citation.volume | 143 | - |
dc.citation.startPage | 28 | - |
dc.citation.endPage | 32 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | IDIOPATHIC HYPEREOSINOPHILIC SYNDROME | - |
dc.subject.keywordPlus | ERYTHROLEUKEMIA-CELLS | - |
dc.subject.keywordPlus | ACETYLATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | BUTYRATE | - |
dc.subject.keywordPlus | LEUKEMIA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordAuthor | EoL-1 cells | - |
dc.subject.keywordAuthor | eosinophils | - |
dc.subject.keywordAuthor | differentiation | - |
dc.subject.keywordAuthor | histone deacetylase inhibitors | - |
dc.subject.keywordAuthor | FIP1L1 | - |
dc.subject.keywordAuthor | PDGFRA | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.