Hydrogen peroxide activates p70(S6k) signaling pathway
DC Field | Value | Language |
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dc.contributor.author | Bae, GU | - |
dc.contributor.author | Seo, DW | - |
dc.contributor.author | Kwon, HK | - |
dc.contributor.author | Lee, HY | - |
dc.contributor.author | Hong, S | - |
dc.contributor.author | Lee, ZW | - |
dc.contributor.author | Ha, KS | - |
dc.contributor.author | Lee, HW | - |
dc.contributor.author | Han, JW | - |
dc.date.accessioned | 2022-04-19T13:06:30Z | - |
dc.date.available | 2022-04-19T13:06:30Z | - |
dc.date.issued | 1999-11 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.issn | 1083-351X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/150177 | - |
dc.description.abstract | We investigated a possible role of reactive oxygen species (ROS) in p70(S6k) activation, which plays an important role in the progression of cells from G(0)/G(1) to S phase of the cell cycle by translational up-regulation of a family of mRNA transcripts that encode for components of the protein synthetic machinery. Treatment of mouse epidermal cell JB6 with H2O2 generated extracellularly by glucose/glucose oxidase led to the activation of p70(S6k) and p90(Rsk) and to phosphorylation of p42(MAPK)/p44(MAPK) The activation of p70(S6k) and p90(Rsk) was dose-dependent and transient, maximal activities being in extracts treated for 15 and 30 min, respectively. Further characterization of ROS-induced activation of p70S6k using specific inhibitors for p70S6k Signaling pathway, rapamycin, and wortmannin revealed that ROS acted upstream of the rapamycin-sensitive component FRAP/RAFT and wortmannin-sensitive component phosphatidylinositol 3-kinase, because both inhibitors caused the inhibition of ROS-induced p70(S6k) activity. In addition, Ca2+ chelation also inhibited ROS-induced activation of p70S6k, indicating that Ca2+ is a mediator of p70(S6k) activation by ROS. However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PHC in | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER | - |
dc.title | Hydrogen peroxide activates p70(S6k) signaling pathway | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1074/jbc.274.46.32596 | - |
dc.identifier.scopusid | 2-s2.0-0032731347 | - |
dc.identifier.wosid | 000083623000013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.274, no.46, pp 32596 - 32602 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 274 | - |
dc.citation.number | 46 | - |
dc.citation.startPage | 32596 | - |
dc.citation.endPage | 32602 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
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