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Polyethylene glycol-grafted poly-l-lysine as polymeric gene carrier

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dc.contributor.authorYoung Hun Choi-
dc.contributor.authorFeng Liu-
dc.contributor.authorJin-Seok Kim-
dc.contributor.authorYoung Kweon Choi-
dc.contributor.authorJong Sang Park-
dc.contributor.authorSung Wan Kim-
dc.date.accessioned2022-04-19T13:23:51Z-
dc.date.available2022-04-19T13:23:51Z-
dc.date.issued1998-06-
dc.identifier.issn0168-3659-
dc.identifier.issn1873-4995-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/150360-
dc.description.abstractA new series of gene carriers, polyethylene glycol (PEG)-grafted poly-l-lysine (PLL, mol. wt.=25 000) with three different PEG-grafted ratios (5, 10 and 25 mole%, which means 5, 10 and 25% of ϵ-amino group of PLL was modified by PEG), was synthesized. These new gene carriers, named comb-shaped PEG-g-PLL copolymer, showed a 5- to 30-fold increase in transfection efficiency compared to PLL alone on a human carcinoma cell line. It is likely that Hep G2 cells were transfected by plasmid DNA/PEG-g-PLL complexes through an endocytosis mechanism due to the fact that chloroquine increased transfection efficiency. Although Lipofectin™, a cationic lipid formulation, showed slightly higher transfection efficiency than PEG-g-PLL in Hep G2 cells, our designed PEG-g-PLL demonstrated lower cytotoxicity, early gene expression and maintenance of gene expression for up to 96 h.-
dc.format.extent10-
dc.language영어-
dc.language.isoENG-
dc.publisherElsevier BV-
dc.titlePolyethylene glycol-grafted poly-l-lysine as polymeric gene carrier-
dc.typeArticle-
dc.publisher.location네델란드-
dc.identifier.doi10.1016/S0168-3659(97)00174-0-
dc.identifier.scopusid2-s2.0-0002656438-
dc.identifier.wosid000074043000005-
dc.identifier.bibliographicCitationJournal of Controlled Release, v.54, no.1, pp 39 - 48-
dc.citation.titleJournal of Controlled Release-
dc.citation.volume54-
dc.citation.number1-
dc.citation.startPage39-
dc.citation.endPage48-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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