Polyethylene glycol-grafted poly-l-lysine as polymeric gene carrier
DC Field | Value | Language |
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dc.contributor.author | Young Hun Choi | - |
dc.contributor.author | Feng Liu | - |
dc.contributor.author | Jin-Seok Kim | - |
dc.contributor.author | Young Kweon Choi | - |
dc.contributor.author | Jong Sang Park | - |
dc.contributor.author | Sung Wan Kim | - |
dc.date.accessioned | 2022-04-19T13:23:51Z | - |
dc.date.available | 2022-04-19T13:23:51Z | - |
dc.date.issued | 1998-06 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.issn | 1873-4995 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/150360 | - |
dc.description.abstract | A new series of gene carriers, polyethylene glycol (PEG)-grafted poly-l-lysine (PLL, mol. wt.=25 000) with three different PEG-grafted ratios (5, 10 and 25 mole%, which means 5, 10 and 25% of ϵ-amino group of PLL was modified by PEG), was synthesized. These new gene carriers, named comb-shaped PEG-g-PLL copolymer, showed a 5- to 30-fold increase in transfection efficiency compared to PLL alone on a human carcinoma cell line. It is likely that Hep G2 cells were transfected by plasmid DNA/PEG-g-PLL complexes through an endocytosis mechanism due to the fact that chloroquine increased transfection efficiency. Although Lipofectin™, a cationic lipid formulation, showed slightly higher transfection efficiency than PEG-g-PLL in Hep G2 cells, our designed PEG-g-PLL demonstrated lower cytotoxicity, early gene expression and maintenance of gene expression for up to 96 h. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Polyethylene glycol-grafted poly-l-lysine as polymeric gene carrier | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/S0168-3659(97)00174-0 | - |
dc.identifier.scopusid | 2-s2.0-0002656438 | - |
dc.identifier.wosid | 000074043000005 | - |
dc.identifier.bibliographicCitation | Journal of Controlled Release, v.54, no.1, pp 39 - 48 | - |
dc.citation.title | Journal of Controlled Release | - |
dc.citation.volume | 54 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 48 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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