Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jong-Tae | - |
dc.contributor.author | Cho, Mi-Young | - |
dc.contributor.author | Choi, Seung-Chul | - |
dc.contributor.author | Kim, Jung Woo | - |
dc.contributor.author | Chae, Suhn-Kee | - |
dc.contributor.author | Yoon, Do-Young | - |
dc.contributor.author | Kim, Jae Wha | - |
dc.contributor.author | Lim, Jong-Seok | - |
dc.date.available | 2021-02-22T15:17:55Z | - |
dc.date.issued | 2006-10 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15054 | - |
dc.description.abstract | The prenylated Rab acceptor 1 (PRA1) is a ubiquitously expressed 21 kDa protein containing two transmembrane domains that possibly induce its localization to the Golgi complex. It binds to prenylated Rab GTPases and VAMP2. In this study, we report that PRA1-overexpressing cells exhibited a significantly retarded growth rate as compared to that of the mock-transfected cells, and the transcriptional activity of TCF, as evaluated by TOPflash luciferase reporter assay, was profoundly reduced in the PRA1-overexpressed cells. These intracellular functions of PRA1 were verified by introducing deletion mutant or site-directed mutants, or small interfering RNA of PRA1 In addition, the translocation of beta-catenin from the cytosol to the nucleus was blocked to a significant degree in the PRAI-cells, and the interaction of PRA1 and beta-catenin was identified by confocal microscopy and immunoprecipitation analysis. Finally, we observed that the inhibition of TCF/beta-catenin signaling by PRA1 is associated with ERK1/2 dephosphorylation. Therefore, our data suggest that the in vivo modulation of PRAI may be involved in TCF/beta-catenin signaling, as well as cellular proliferation and tumorigenesis. (c) 2006 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.08.026 | - |
dc.identifier.scopusid | 2-s2.0-33748329579 | - |
dc.identifier.wosid | 000240650000027 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.349, no.1, pp 200 - 208 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 349 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 200 | - |
dc.citation.endPage | 208 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | RAB ACCEPTOR PRA1 | - |
dc.subject.keywordPlus | PRENYLATED RAB | - |
dc.subject.keywordPlus | SMALL GTPASES | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | SUPERFAMILY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | prenylated Rab acceptor 1 (PRA1) | - |
dc.subject.keywordAuthor | luciferase reporter assay | - |
dc.subject.keywordAuthor | TCF | - |
dc.subject.keywordAuthor | beta-catenin signaling | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.