Antitumor responses of adoptively-transferred tumor-specific T-cell cultures in a murine lymphoma model
DC Field | Value | Language |
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dc.contributor.author | Hee Sue Kim | - |
dc.contributor.author | Hee Gu Lee | - |
dc.contributor.author | Lim, Jong Seok | - |
dc.contributor.author | Ki Young Lee | - |
dc.contributor.author | Jaewha Kim | - |
dc.contributor.author | Kyeong Soo Chung | - |
dc.contributor.author | Yong Kyung Choe | - |
dc.contributor.author | In Seong Choe | - |
dc.contributor.author | Tai Wha Chung | - |
dc.contributor.author | Kilhyoun Kim | - |
dc.date.accessioned | 2022-04-19T14:02:46Z | - |
dc.date.available | 2022-04-19T14:02:46Z | - |
dc.date.issued | 1995-11 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/150882 | - |
dc.description.abstract | The purpose of this study was to establish an in vitro culture method of tumor-specific T cells, and determine the efficacy of the cultured tumor-specific cytotoxic T-lymphocytes (GTL) as an agent of anti-tumor immunotherapy against a murine lymphoma, TIMI.4. Tumor-specific T-lymphocytes derived from C57BL/6 mice (thy-1.2) immune to TIMI.4 were activated by in vitro stimulation with the irradiated TIMI.4 cells, and expanded by restimulation with TIML4 in the presence of the concanavalin A-stimulated mt spleen culture supernatant, and splenic antigen-presenting cells. In vitro restimulation enhanced markedly the proportion of CD8^+, a predominant surface marker of CTL, and the cytotoxic activity in the cultured immune T cell population. The resulting TIMI.4-specific T cells were adoptively transferred into nude mice. The tumor cells residing in the host after 7 days of adoptive transfer to B6.PL (thy-1.1) mice were quantified by use of an antibody directed to the thy-1.2 allele. The TIMI.4 cells in the recipient nude mice were decreased in a dose-dependent manner. Anti-tumor activity of the TIMI.4-specific T cells was also demonstrated by a survival test, where the tumor-bearing nu/nu mice which received the activated T-cells survived about 30% longer than the control mice which received the tumor cells alone. These suggest that adoptive transfer of TIMI.4-specific T cells could be a candidate for effective therapy of the murine lymphoma. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Antitumor responses of adoptively-transferred tumor-specific T-cell cultures in a murine lymphoma model | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | Journal of Biochemistry and Molecular Biology, v.28, no.6, pp 556 - 561 | - |
dc.citation.title | Journal of Biochemistry and Molecular Biology | - |
dc.citation.volume | 28 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 556 | - |
dc.citation.endPage | 561 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | domestic | - |
dc.identifier.url | https://kiss.kstudy.com/thesis/thesis-view.asp?key=118045 | - |
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