신규 퀴놀론계 항생물질 DWQ-013의 흰쥐 및 생쥐에서의 체내동태
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조재열 | - |
dc.contributor.author | 남권호 | - |
dc.contributor.author | 김동오 | - |
dc.contributor.author | 이종완 | - |
dc.contributor.author | 박남준 | - |
dc.contributor.author | 강영숙 | - |
dc.contributor.author | 유영효 | - |
dc.contributor.author | 이재욱 | - |
dc.date.accessioned | 2022-04-22T02:00:08Z | - |
dc.date.available | 2022-04-22T02:00:08Z | - |
dc.date.issued | 1995-06 | - |
dc.identifier.issn | 0377-9556 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/151280 | - |
dc.description.abstract | The pharmacokinetics and tissue distribution of DWQ-013, a new quinolone, were examined in rats and mice following a single intravenous and oral administration. DWQ-013 in plasma and urine was determined by both HPLC and microbiological assay. The plasma concentration of the drug declined biexpohentially. The terminal half life of the drug was 1.11 +/- 0.14 hour after intravenous dosing. The volume of distribution at terminal elimination phase(Vdbeta) and total clearance of the drug were 1.29 +/- 0.15l/kg and 0.78 +/- 0.09 l/h/kg. The bioavailability of DWQ-013 after oral administration was 56.0%(HPLC) and 77.2%(bioassay), respectively. Twelve-hour urinary recovery of drug was measured by HPLC and bioassay to 0.035 +/- 0.009% and 4.71 +/- 0.66% after oral dosing, to 0.055 +/- 0.014% and 7.65 +/- 1.53% after intravenous dosing, which may indicate the presence of biologically active metabolites. Binding of the drug to plasma proteins ranged from 97%-99% at various concentrations. The drug was highly distributed in order of liver, kidney and lung after 1.5 hours in mice. | - |
dc.format.extent | 8 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한약학회 | - |
dc.title | 신규 퀴놀론계 항생물질 DWQ-013의 흰쥐 및 생쥐에서의 체내동태 | - |
dc.title.alternative | Pharmacokinetic Study on DWQ-013, a New Quinolone, in Rats and Mice | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | 약 학 회 지, v.39, no.3, pp 223 - 230 | - |
dc.citation.title | 약 학 회 지 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 223 | - |
dc.citation.endPage | 230 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | domestic | - |
dc.identifier.url | http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010023998457 | - |
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