Nanotheranostics of Pre-Stenotic Vessels By Target Touch-On Signaling of Peptide Navigator
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Seung Eun | - |
dc.contributor.author | Chung, Seyong | - |
dc.contributor.author | Ha, Hyun-Su | - |
dc.contributor.author | Kim, Dae-Hyun | - |
dc.contributor.author | Baek, Sewoom | - |
dc.contributor.author | Kim, Tae Young | - |
dc.contributor.author | Lee, Songhyun | - |
dc.contributor.author | Yoon, Hyo-Jin | - |
dc.contributor.author | Chung, Soon Won | - |
dc.contributor.author | Lee, Jung Bok | - |
dc.contributor.author | Shin, Young Min | - |
dc.contributor.author | Kim, Hye-Seon | - |
dc.contributor.author | Kim, Si Young | - |
dc.contributor.author | Park, Joon-Sang | - |
dc.contributor.author | Kim, Chang-Soo | - |
dc.contributor.author | Sung, Hak-Joon | - |
dc.date.accessioned | 2022-04-26T02:20:03Z | - |
dc.date.available | 2022-04-26T02:20:03Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.issn | 1616-3028 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/151301 | - |
dc.description.abstract | Navigation of nanoparticles to target sites of blood flow disturbance markedly upgrades the diagnostic paradigm in vascular medicine. The theranostic treatment of pre-stenotic vessels can prevent the irreversible occlusion process effectively. Here, these nanotheranostic functions are established by displaying CDK9(cyclin-dependent kinase 9)-targeting peptide (P.) onto nanovesicles (NV) and liposomes using the navigation function and subsequent binding-on signaling of P. as a game-changer. When rabbit vessels are allografted with injecting contrast-loaded P. liposomes, the case-dependent stenotic degree after 2-6 weeks can be diagnosed accurately within 2-4 days via computed tomography imaging with cross-validation in a mouse model of partial carotid ligation. Furthermore, the anti-CDK9 signaling of P. NV is activated post-targeting and effectively prevents vascular stenosis by suppressing inflammation and lipotoxicity in the vessels, serum, and/or liver. CDK9 targeting is confirmed using computer, in vitro, and in vivo models. This study demonstrates an unprecedented nanotheranostic function for future clinical applications. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Nanotheranostics of Pre-Stenotic Vessels By Target Touch-On Signaling of Peptide Navigator | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1002/adfm.202110368 | - |
dc.identifier.scopusid | 2-s2.0-85120793028 | - |
dc.identifier.wosid | 000728141300001 | - |
dc.identifier.bibliographicCitation | ADVANCED FUNCTIONAL MATERIALS, v.32, no.15, pp 1 - 13 | - |
dc.citation.title | ADVANCED FUNCTIONAL MATERIALS | - |
dc.citation.volume | 32 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MONOCYTES | - |
dc.subject.keywordAuthor | CDK9 | - |
dc.subject.keywordAuthor | disturbed flow | - |
dc.subject.keywordAuthor | nanotheranostics | - |
dc.subject.keywordAuthor | pre-stenotic vessel | - |
dc.subject.keywordAuthor | targeting peptide | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/epdf/10.1002/adfm.202110368 | - |
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