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Hornerin mediates phosphorylation of the polo-box domain in Plk1 by Chk1 to induce death in mitosis

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dc.contributor.authorSong, Haiyu-
dc.contributor.authorKim, Eun Ho-
dc.contributor.authorHong, Jihee-
dc.contributor.authorGwon, Dasom-
dc.contributor.authorKim, Jee Won-
dc.contributor.authorBae, Gyu-Un-
dc.contributor.authorJang, Chang-Young-
dc.date.accessioned2023-11-08T05:44:14Z-
dc.date.available2023-11-08T05:44:14Z-
dc.date.issued2023-09-
dc.identifier.issn1350-9047-
dc.identifier.issn1476-5403-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/151601-
dc.description.abstractThe centrosome assembles a bipolar spindle for faithful chromosome segregation during mitosis. To prevent the inheritance of DNA damage, the DNA damage response (DDR) triggers programmed spindle multipolarity and concomitant death in mitosis through a poorly understood mechanism. We identified hornerin, which forms a complex with checkpoint kinase 1 (Chk1) and polo-like kinase 1 (Plk1) to mediate phosphorylation at the polo-box domain (PBD) of Plk1, as the link between the DDR and death in mitosis. We demonstrate that hornerin mediates DDR-induced precocious centriole disengagement through a dichotomous mechanism that includes sequestration of Sgo1 and Plk1 in the cytoplasm through phosphorylation of the PBD in Plk1 by Chk1. Phosphorylation of the PBD in Plk1 abolishes the interaction with Sgo1 and phosphorylation-dependent Sgo1 translocation to the centrosome, leading to precocious centriole disengagement and spindle multipolarity. Mechanistically, hornerin traps phosphorylated Plk1 in the cytoplasm. Furthermore, PBD phosphorylation inactivates Plk1 and disrupts Cep192::Aurora A::Plk1 complex translocation to the centrosome and concurrent centrosome maturation. Remarkably, hornerin depletion leads to chemoresistance against DNA damaging agents by attenuating DDR-induced death in mitosis. These results reveal how the DDR eradicates mitotic cells harboring DNA damage to ensure genome integrity during cell division.-
dc.format.extent16-
dc.language영어-
dc.language.isoENG-
dc.publisherSPRINGERNATURE-
dc.titleHornerin mediates phosphorylation of the polo-box domain in Plk1 by Chk1 to induce death in mitosis-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1038/s41418-023-01208-y-
dc.identifier.scopusid2-s2.0-85168350820-
dc.identifier.wosid001051211700002-
dc.identifier.bibliographicCitationCELL DEATH AND DIFFERENTIATION, v.30, no.9, pp 2151 - 2166-
dc.citation.titleCELL DEATH AND DIFFERENTIATION-
dc.citation.volume30-
dc.citation.number9-
dc.citation.startPage2151-
dc.citation.endPage2166-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusDNA-DAMAGE RESPONSE-
dc.subject.keywordPlusMITOTIC CATASTROPHE-
dc.subject.keywordPlusCHROMOSOMAL INSTABILITY-
dc.subject.keywordPlusSPINDLE MULTIPOLARITY-
dc.subject.keywordPlusCENTRIOLE COHESION-
dc.subject.keywordPlusSTRUCTURAL BASIS-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusCHECKPOINT-
dc.subject.keywordPlusKINASE-
dc.subject.keywordPlusDUPLICATION-
dc.identifier.urlhttps://www.nature.com/articles/s41418-023-01208-y-
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