A specific and rapid HPLC assay for the determination of cefroxadine in human plasma and its application to pharmacokinetic study in Korean
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, YS | - |
dc.contributor.author | Lee, SY | - |
dc.contributor.author | Kim, NH | - |
dc.contributor.author | Choi, HM | - |
dc.contributor.author | Park, JS | - |
dc.contributor.author | Kim, W | - |
dc.contributor.author | Lee, HJ | - |
dc.date.available | 2021-02-22T15:31:17Z | - |
dc.date.issued | 2006-02 | - |
dc.identifier.issn | 0731-7085 | - |
dc.identifier.issn | 1873-264X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15180 | - |
dc.description.abstract | A specific and rapid high performance liquid chromatographic (HPLC) method with UV detection (254 nm) was developed for the determination of cefroxadine in human plasma. The sample extraction was performed by a simple procedure, vortexing and centrifugation of sample following addition of 60% trichloroacetic acid. Cephalexin was used as an internal standard (I.S.). The HPLC analysis was carried out on a Capcell Pak C-18 analytical column with a mobile phase of 50 mM ammonium formate buffer/pH 3.5 and acetonitrile. (90: 10, v/v). No interference was observed near the peaks of cefroxadine and I.S. The calibration curve was linear over the range of 0.5-40 mu g/mL and the lower limit of quantification (LLOQ) was 0.5 mu g/mL. The method was validated with excellent sensitivity, accuracy, precision and stability. This assay was successfully applied to determine the pharmacokinetic parameters of cefroxadine in Korean healthy volunteers after an oral administration of two 250 mg cefroxadine capsules. As a result, the plasma half-life was 1.00 +/- 0.26 h and the mean AUCO-6 h was 46.25 +/- 6.41 mu g h/mL. The maximum plasma concentration (C-max) Of 17.62 +/- 4.87 mu g/mL reached 1.44 +/- 0.39 h after administration. (c) 2005 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | A specific and rapid HPLC assay for the determination of cefroxadine in human plasma and its application to pharmacokinetic study in Korean | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jpba.2005.07.026 | - |
dc.identifier.scopusid | 2-s2.0-31344474216 | - |
dc.identifier.wosid | 000235319100019 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, v.40, no.2, pp 369 - 374 | - |
dc.citation.title | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - |
dc.citation.volume | 40 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 369 | - |
dc.citation.endPage | 374 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | HEALTHY-VOLUNTEERS | - |
dc.subject.keywordPlus | CGP 9000 | - |
dc.subject.keywordPlus | RENAL-FUNCTION | - |
dc.subject.keywordPlus | CEPHALOSPORIN | - |
dc.subject.keywordPlus | CGP-9000 | - |
dc.subject.keywordPlus | CEPHALEXIN | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordAuthor | cefroxadine | - |
dc.subject.keywordAuthor | HPLC | - |
dc.subject.keywordAuthor | human plasma | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
dc.subject.keywordAuthor | validation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.