Luteolin inhibits LPS-stimulated inducible nitric oxide synthase expression in BV-2 microglial cells
DC Field | Value | Language |
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dc.contributor.author | Kim, JS | - |
dc.contributor.author | Lee, HJ | - |
dc.contributor.author | Lee, MH | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Jin, C | - |
dc.contributor.author | Ryu, JH | - |
dc.date.available | 2021-02-22T15:31:31Z | - |
dc.date.issued | 2006-01 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.issn | 1439-0221 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15208 | - |
dc.description.abstract | Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) acts as a neurotoxic effector in the central nervous system, resulting in neurodegenerative diseases. From the alcoholic extracts of Perilla frutescens, we have purified an inhibitor of NO production in lipopolysaccharide (LPS)-activated microglia by activity-guided purification. The active compound was identified as luteolin by spectral analysis. Luteolin inhibited the NO production in LPS-activated microglia in a dose-dependent manner (IC50 = 6.9 mu M). Luteolin also suppressed the degradation of I-kappa B-alpha, the expression of protein and rnRNA of iNOS in LPS-activated microglia as observed in Western blot analysis and RT-PCR experiments. Luteolin may have beneficial effects in the treatment of neuro-inflammatory diseases through the inhibition of NOS expression. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.title | Luteolin inhibits LPS-stimulated inducible nitric oxide synthase expression in BV-2 microglial cells | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1055/s-2005-873145 | - |
dc.identifier.scopusid | 2-s2.0-32644433270 | - |
dc.identifier.wosid | 000235605700013 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.72, no.1, pp 65 - 68 | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 72 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 68 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PERILLA-FRUTESCENS | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | ENZYME | - |
dc.subject.keywordPlus | BRAIN | - |
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