Long-Term Risk of Cardiovascular Disease Among Type 2 Diabetes Patients According to Average and Visit-to-Visit Variations of HbA1c Levels During the First 3 Years of Diabetes Diagnosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyunah | - |
dc.contributor.author | Jung, Da Young | - |
dc.contributor.author | Lee, Seung-Hwan | - |
dc.contributor.author | Cho, Jae-Hyoung | - |
dc.contributor.author | Yim, Hyeon Woo | - |
dc.contributor.author | Kim, Hun-Sung | - |
dc.date.accessioned | 2023-11-08T06:53:14Z | - |
dc.date.available | 2023-11-08T06:53:14Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/152108 | - |
dc.description.abstract | BACKGROUND: It remains unclear whether a combination of glycemic variability and glycated hemoglobin (HbA1c) status leads to a higher incidence of cardiovascular disease (CVD). Therefore, to investigate CVD risk according to the glucose control status during early diabetes, we examined visit-to-visit HbA1c variability among patients with type 2 diabetes (T2DM). METHODS: In this 9-year retrospective study, we measured HbA1c levels at each visit and tracked the change in HbA1c levels for 3 years after the first presentation (observation window) in newly diagnosed T2DM patients. We later assessed the occurrence of CVD in the last 3 years (target outcome window) of the study period after allowing a 3-year buffering window. The HbA1c variability score (HVS; divided into quartiles, HVS_Q1-4) was used to determine visit-to-visit HbA1c variability. RESULTS: Among 4,817 enrolled T2DM patients, the mean HbA1c level was < 7% for the first 3 years. The group with the lowest HVS had the lowest rate of CVD (9.4%; 104/1,109 patients). The highest incidence of CVD of 26.7% (8/30 patients) was found in HVS [≥ 9.0%]_Q3, which was significantly higher than that in HVS [6.0-6.9%]_Q1 (P = 0.006), HVS [6.0-6.9%]_Q2 (P = 0.013), HVS [6.0-6.9%]_Q3 (P = 0.018), and HVS [7.0-7.9%]_Q3 (P = 0.040). CONCLUSION: To our knowledge, this is the first long-term study to analyze the importance of both HbA1c change and visit-to-visit HbA1c variability during outpatient visits within the first 3 years. Lowering glucose levels during early diabetes may be more critical than reducing visit-to-visit HbA1c variability. © 2023 The Korean Academy of Medical Sciences. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한의학회 (The Korean Academy of Medical Sciences) | - |
dc.title | Long-Term Risk of Cardiovascular Disease Among Type 2 Diabetes Patients According to Average and Visit-to-Visit Variations of HbA1c Levels During the First 3 Years of Diabetes Diagnosis | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3346/jkms.2023.38.e24 | - |
dc.identifier.scopusid | 2-s2.0-85147151573 | - |
dc.identifier.wosid | 000978261100007 | - |
dc.identifier.bibliographicCitation | Journal of Korean medical science, v.38, no.4, pp 1 - 13 | - |
dc.citation.title | Journal of Korean medical science | - |
dc.citation.volume | 38 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002926930 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | MICROVASCULAR COMPLICATIONS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordAuthor | Blood Glucose | - |
dc.subject.keywordAuthor | Cardiovascular Disease | - |
dc.subject.keywordAuthor | Diabetes Mellitus | - |
dc.subject.keywordAuthor | Glycated Hemoglobin (HbA1c) | - |
dc.subject.keywordAuthor | HbA1c Variability Score | - |
dc.identifier.url | https://jkms.org/DOIx.php?id=10.3346/jkms.2023.38.e24 | - |
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