덱스트로메트르판이 마우스의 일차 체액성 면역반응에 미치는 영향

Abstract

Dextromethorphan hydrobromide (DXM) has been widely used as a nonopioid antitussive drug with lowtoxicity and low potential for drug dependency. DXM is a psychotropic drug since 2003 in our country. Thisto DXM dissolved in saline as concentration of 30, 60, and 120 mg/kg b.w. before (day-2) or after (day+ 2)immunization (OVA-antigen, day 0). Thereafter, we measured the increased rate of body weight, relativeweight of organ(thymus, spleen, liver, kidney) and OVA-cytes were exposed to various concentration of DXM(0.001~ 100M) and cultured with B cell mitogen(LPS)and splenocytes proliferations (SP) were measured by MTT-assay. Thymus-weight were slightly changed onday 9 after administration of DXM, but body-, spleen-, liver-, and kidney-control group and DXM-treated group. SP to LPS were significantly decreased at high concentration(100M)when compared with controls. When DXM was administered before or after immunization with OVA-antigen,OVA-specific IgM levels were significantly lowered in a dose-dependent manner. These results indicate thatDXM may depress the primary humoral immune response to the initial antigenic challenge.