Reduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, Yesol | - |
dc.contributor.author | Ko, Je Yeong | - |
dc.contributor.author | Lee, Soo-Been | - |
dc.contributor.author | Oh, Sumin | - |
dc.contributor.author | Park, Jee Won | - |
dc.contributor.author | Kang, Hyeok-Gu | - |
dc.contributor.author | Kim, Da-Hyun | - |
dc.contributor.author | Chung, Daeun | - |
dc.contributor.author | Lim, Sera | - |
dc.contributor.author | Kong, Hyunkyung | - |
dc.contributor.author | Kim, Jongmin | - |
dc.contributor.author | Yoo, Kyung Hyun | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Chun, Kyung-Hee | - |
dc.contributor.author | Park, Jong Hoon | - |
dc.date.accessioned | 2023-11-08T09:46:06Z | - |
dc.date.available | 2023-11-08T09:46:06Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.issn | 1476-5594 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/152777 | - |
dc.description.abstract | Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer; however, specific prognostic biomarkers have not yet been developed. In this study, we identified dysregulated microRNAs (miRNAs) in TNBC by profiling miRNA and mRNA expression. In patients with TNBC, miR-371b-5p expression was reduced, and miR-371b-5p overexpression significantly mitigated TNBC cell growth, migration, and invasion. In addition, we found that expression of cold shock domain-containing protein E1 (CSDE1), a direct target gene of miR-371b-5p, was upregulated in TNBC cells, and inhibition of CSDE1 expression alleviated TNBC cell growth by regulating RAC1 transcription. Mechanistically, CSDE1, phosphorylated C-terminal domain (p-CTD) of RNA polymerase II (RNAPII), and CDK7 form a complex, and downregulation of CSDE1 leads to weak interaction between RNAPII p-CTD and CDK7, resulting in a decrease in RNAPII p-CTD expression to reduce RAC1 transcript levels in CSDE1-deficient TNBC cells. Our data demonstrate that miR-371b-5p is a tumor-suppressive miRNA that regulates the CSDE1/Rac1 axis and could be a potential prognostic biomarker for TNBC. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGERNATURE | - |
dc.title | Reduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41388-022-02326-6 | - |
dc.identifier.scopusid | 2-s2.0-85129126692 | - |
dc.identifier.wosid | 000789076800001 | - |
dc.identifier.bibliographicCitation | ONCOGENE, v.41, no.22, pp 3151 - 3161 | - |
dc.citation.title | ONCOGENE | - |
dc.citation.volume | 41 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 3151 | - |
dc.citation.endPage | 3161 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | RNA-BINDING PROTEIN | - |
dc.subject.keywordPlus | COLD-SHOCK DOMAINS | - |
dc.subject.keywordPlus | NEOADJUVANT CHEMOTHERAPY | - |
dc.subject.keywordPlus | CELL-MIGRATION | - |
dc.subject.keywordPlus | MICRORNAS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | UNR | - |
dc.identifier.url | https://www.nature.com/articles/s41388-022-02326-6 | - |
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