Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling
DC Field | Value | Language |
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dc.contributor.author | Keun Il Kim | - |
dc.contributor.author | Ming Yan | - |
dc.contributor.author | Oxana Malakohva | - |
dc.contributor.author | Luo, Jiann-Kae | - |
dc.contributor.author | Mei-Feng Shen | - |
dc.contributor.author | Weiguo Zou | - |
dc.contributor.author | Juan Carlos de la Torre | - |
dc.contributor.author | Dong-Er Zhang | - |
dc.date.available | 2021-02-22T15:33:09Z | - |
dc.date.issued | 2006-01 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.issn | 1098-5549 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15400 | - |
dc.description.abstract | The expression of ubiquitin-Iike modifier ISG15 and its conjugation to target proteins are highly induced by interferon (IFN) stimulation and during viral and bacterial infections. However, the biological significance of this modification has not been clearly understood. To investigate the function of protein modification by ISG15, we generated a mouse model deficient in UBE1L, an ISG15-activating enzyme. Ube1L-/- mice did not produce ISG15 conjugates but expressed free ISG15 normally. ISGylation lias been implicated in the reproduction and innate immunity. However, Ube1L-/- mice were fertile and exhibited normal antiviral responses against vesicular stomatitis virus and lymphocytic choriomeningitis virus infection. Our results indicate that UBE1L and protein ISGylation are not critical for IFN-α/β signaling via JAK/STAT activation. Moreover, using Ube1L/Ubp43 double-deficient mice, we showed that lack of UBP43, but not the increase of protein ISGylation, is related to the increased IFN signaling in Ubp43-deficient mice. Copyright © 2006, American Society for Microbiology. All Rights Reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Society for Microbiology | - |
dc.title | Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1128/MCB.26.2.472-479.2006 | - |
dc.identifier.scopusid | 2-s2.0-30644470650 | - |
dc.identifier.bibliographicCitation | Molecular and Cellular Biology, v.26, no.2, pp 472 - 479 | - |
dc.citation.title | Molecular and Cellular Biology | - |
dc.citation.volume | 26 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 472 | - |
dc.citation.endPage | 479 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | alpha interferon | - |
dc.subject.keywordPlus | beta interferon | - |
dc.subject.keywordPlus | enzyme | - |
dc.subject.keywordPlus | gene product | - |
dc.subject.keywordPlus | interferon | - |
dc.subject.keywordPlus | Janus kinase | - |
dc.subject.keywordPlus | protein ISG15 | - |
dc.subject.keywordPlus | protein Ube1L | - |
dc.subject.keywordPlus | protein Ubp43 | - |
dc.subject.keywordPlus | proteinase | - |
dc.subject.keywordPlus | STAT protein | - |
dc.subject.keywordPlus | ubiquitin | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | embryo | - |
dc.subject.keywordPlus | enzyme activation | - |
dc.subject.keywordPlus | fertility | - |
dc.subject.keywordPlus | innate immunity | - |
dc.subject.keywordPlus | Lymphocytic choriomeningitis virus | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | protein modification | - |
dc.subject.keywordPlus | reproduction | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | Vesicular stomatitis virus | - |
dc.subject.keywordPlus | virus infection | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Apoptosis | - |
dc.subject.keywordPlus | Arenaviridae Infections | - |
dc.subject.keywordPlus | Cells, Cultured | - |
dc.subject.keywordPlus | Cytokines | - |
dc.subject.keywordPlus | Endopeptidases | - |
dc.subject.keywordPlus | Interferon-alpha | - |
dc.subject.keywordPlus | Interferon-beta | - |
dc.subject.keywordPlus | Lymphocytic choriomeningitis virus | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Mice, Knockout | - |
dc.subject.keywordPlus | Mutation | - |
dc.subject.keywordPlus | Rhabdoviridae Infections | - |
dc.subject.keywordPlus | Signal Transduction | - |
dc.subject.keywordPlus | Ubiquitin-Activating Enzymes | - |
dc.subject.keywordPlus | Ubiquitins | - |
dc.subject.keywordPlus | Vesicular stomatitis-Indiana virus | - |
dc.subject.keywordPlus | Animalia | - |
dc.subject.keywordPlus | Bacteria (microorganisms) | - |
dc.subject.keywordPlus | Lymphocytic choriomeningitis virus | - |
dc.subject.keywordPlus | Vesicular stomatitis virus | - |
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