Rolipram, a phosphodiesterase 4 inhibitor, stimulates inducible cAMP early repressor expression in osteoblasts
DC Field | Value | Language |
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dc.contributor.author | Cho, ES | - |
dc.contributor.author | Yu, JH | - |
dc.contributor.author | Kim, MS | - |
dc.contributor.author | Yim, M | - |
dc.date.available | 2021-02-22T15:47:11Z | - |
dc.date.issued | 2005-02 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.issn | 1976-2437 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15534 | - |
dc.description.abstract | Phosphodiesterase (PDE) 4 inhibitors have been shown to induce the cAMP-mediated signaling pathway by inhibiting cAMP hydrolysis. This study investigated the effect of a PDE4 inhibitor on the expression of the inducible cAMP early repressor (ICER), which is an endogenous inhibitor of CRE-mediated transcription, in osteoblastic cells. RT-PCR analysis revealed that rolipram, a PDE4 inhibitor, stimulates the ICER mRNA in a dose dependent manner. The induction of ICER mRNA expression by rolipram was suppressed by the inhibitors of protein kinase A (PKA) and p38 MAPK, suggesting the involvement of PKA and p38 MAPK activation in ICER expression by rolipram. It was previously shown that rolipram induced the expression of TNF-related activation-induced cytokine (TRANCE, also known as RANKL, ODF, or OPGL) in osteoblasts. This paper provides evidences that a transcriptional repressor like ICER might modulate TRANCE mRNA expression by rolipram in osteoblasts. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.title | Rolipram, a phosphodiesterase 4 inhibitor, stimulates inducible cAMP early repressor expression in osteoblasts | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3349/ymj.2005.46.1.149 | - |
dc.identifier.scopusid | 2-s2.0-14944370007 | - |
dc.identifier.wosid | 000227584300020 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.46, no.1, pp 149 - 154 | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 46 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 149 | - |
dc.citation.endPage | 154 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001118831 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | KAPPA-B LIGAND | - |
dc.subject.keywordPlus | PARATHYROID-HORMONE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE | - |
dc.subject.keywordPlus | OSTEOCLAST DIFFERENTIATION | - |
dc.subject.keywordPlus | RECEPTOR ACTIVATOR | - |
dc.subject.keywordPlus | MC3T3-E1 CELLS | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordAuthor | osteoblast | - |
dc.subject.keywordAuthor | cyclic AMP | - |
dc.subject.keywordAuthor | PDE4 inhibitor | - |
dc.subject.keywordAuthor | ICER | - |
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