Corticotropin-Releasing Hormone (CRH)에 의한 인간 자연 살해 세포(NK-92MI)의 Migration 억제
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 천소영 | - |
dc.contributor.author | 방사익 | - |
dc.contributor.author | 조대호 | - |
dc.date.available | 2021-02-22T15:47:33Z | - |
dc.date.issued | 2005-12 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.issn | 2092-6685 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15566 | - |
dc.description.abstract | Background: Natural killer (NK) cells are CD3 ( ) CD14 ( ) CD56 ( ) lymphocytes. They play an important role in the body's innate immune response. They can induce spontaneous killing of cancer cells or virus-infected cells via the Fas/Fas ligand or the granzyme/perforin systems. The corticotropin-releasing hormone (CRH) is an important regulator for the body's stress response. It promotes proliferation and migration of various cancer cells through the CRH type 1 receptor under stress, and also inhibits NK or T cell activity. However, the relationship of CRH and NK cell migration to the target has not been confirmed. Herein, we study the effect of CRH on NK cell migration. Methods: We used the human NK cell line, NK-92MI, and tested the expression of CRH receptor type 1 on NK-92MI by RT-PCR. This was to examine the effect of CRH on tumor and NK cell migration, thus NK cells (NK-92MI) were incubated with or without CRH and then each CRH treated cell's migration ability compared to that of the CRH untreated group. Results: We confirmed that CRH receptor type 1 is expressed in NK-92MI. CRH can decrease NK cell migration in a time-/dose-dependent manner. Conclusion: These data suggest CRH can inhibit NK cell migration to target cells. | - |
dc.format.extent | 5 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한면역학회 | - |
dc.title | Corticotropin-Releasing Hormone (CRH)에 의한 인간 자연 살해 세포(NK-92MI)의 Migration 억제 | - |
dc.title.alternative | Inhibition of Cell Migration by Corticotropin-Releasing Hormone (CRH) in Human Natural Killer Cell Line, NK-92MI | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | Immune Network, v.5, no.4, pp 247 - 251 | - |
dc.citation.title | Immune Network | - |
dc.citation.volume | 5 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 247 | - |
dc.citation.endPage | 251 | - |
dc.identifier.kciid | ART000980985 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.subject.keywordAuthor | Corticotropin releasing hormone (CRH) | - |
dc.subject.keywordAuthor | NK cell | - |
dc.subject.keywordAuthor | migration | - |
dc.subject.keywordAuthor | Corticotropin releasing hormone (CRH) | - |
dc.subject.keywordAuthor | NK cell | - |
dc.subject.keywordAuthor | migration | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART000980985 | - |
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