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파골세포 분화에 관여하는 phosphodiesterase isozyme의 규명
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 조은숙 | - |
| dc.contributor.author | 임미정 | - |
| dc.date.available | 2021-02-22T16:01:53Z | - |
| dc.date.issued | 2004-10 | - |
| dc.identifier.issn | 1225-3723 | - |
| dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15828 | - |
| dc.description.abstract | Phosphodiesterases (PDEs) are enzymes that degrade intracellular cAMP and cGMP. In the present study, inhibition of PDE4 was demonstrated to influence osteoclast formation in co-cultures of mouse bone marrow cells and calvarial osteoblasts. Furthermore, PDE4 was shown to modulate mRNA expression of EP4, TRANCE, and COX-2 in calvarial osteoblasts. These results suggest that PDE4 is a key regulator of EP4, TRANCE, and COX-2 expression in osteoblasts, which in turn controls osteoclast formation. | - |
| dc.language | 한국어 | - |
| dc.language.iso | KOR | - |
| dc.publisher | 숙명여자대학교 약학연구소 | - |
| dc.title | 파골세포 분화에 관여하는 phosphodiesterase isozyme의 규명 | - |
| dc.title.alternative | Identification of Phosphodiesterase Isozyme Involved in Osteoclast Formation | - |
| dc.type | Article | - |
| dc.publisher.location | South Korea | - |
| dc.identifier.bibliographicCitation | 약학논문집-숙명여자대학교, v.21, pp 109 - 113 | - |
| dc.citation.title | 약학논문집-숙명여자대학교 | - |
| dc.citation.volume | 21 | - |
| dc.citation.startPage | 109 | - |
| dc.citation.endPage | 113 | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | domestic | - |
| dc.identifier.url | http://www.riss.kr/search/detail/DetailView.do?p_mat_type=1a0202e37d52c72d&control_no=7bf1e808ca48d52affe0bdc3ef48d419 | - |
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