Antiinflammatory effects of genipin, an active principle of gardenia
DC Field | Value | Language |
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dc.contributor.author | Koo, HJ | - |
dc.contributor.author | 송윤선 | - |
dc.contributor.author | Kim, HJ | - |
dc.contributor.author | Lee, YH | - |
dc.contributor.author | Hong, SM | - |
dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Kim, BC | - |
dc.contributor.author | Jin, C | - |
dc.contributor.author | Lim, CJ | - |
dc.contributor.author | Park, EH | - |
dc.date.available | 2021-02-22T16:02:18Z | - |
dc.date.issued | 2004-07 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15853 | - |
dc.description.abstract | Genipin, the aglycone of geniposide, is metabolically produced from the geniposide in body tissues. The purpose of this study is to clarify some pharmacological actions of genipin. Genipin showed concentration-dependent inhibition on lipid peroxidation induced by Fe++/ ascorbate in rat brain homogenate. Genipin exhibited significant topical antiinflammatory effect shown as an inhibition of croton oil-induced ear edema in mice. Nitric oxide (NO) synthesis by inducible nitric oxide synthase (NOS) is increased in inflammatory diseases and leads to cellular injury. Genipin concentration-dependently (50-300 muM) inhibited NO production and NOS expression upon stimulation by lipopolysaccharide/interferon-gamma (IFN-gamma) in RAW 264.7, a murine macrophage cell line. Genipin markedly blocked lipopolysaccharide-evoked degradation of inhibitor-kappaB-beta (IkappaB-beta), indicating that it exhibits inhibitory effect on NO production through the inhibition of nuclear factor-kappaB (NF-kappaB) activation. It was also shown to contain potent antiangiogenic activity in a dose-dependent manner, which was detected by chick embryo chorioallantoic membrane assay. In summary, we demonstrate that genipin possesses antiinflammatory and is a specific hydroxyl radical scavenger. Its antiangiogenic and NO production-inhibitory properties are also presented. (C) 2004 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Antiinflammatory effects of genipin, an active principle of gardenia | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.ejphar.2004.05.031 | - |
dc.identifier.scopusid | 2-s2.0-3042788976 | - |
dc.identifier.wosid | 000222893300016 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, v.495, no.2-3, pp 201 - 208 | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.citation.volume | 495 | - |
dc.citation.number | 2-3 | - |
dc.citation.startPage | 201 | - |
dc.citation.endPage | 208 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | IRIDOID GLUCOSIDES | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | GENIPOSIDE | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | antiinflammatory | - |
dc.subject.keywordAuthor | genipin | - |
dc.subject.keywordAuthor | inducible nitric oxide synthase | - |
dc.subject.keywordAuthor | lipid peroxidation | - |
dc.subject.keywordAuthor | NO (Nitric oxide) | - |
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