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Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists

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dc.contributor.authorRyu, CH-
dc.contributor.authorJang, MJ-
dc.contributor.authorJung, JW-
dc.contributor.authorPark, JH-
dc.contributor.authorChoi, HY-
dc.contributor.authorSuh, YG-
dc.contributor.authorOh, U-
dc.contributor.authorPark, HG-
dc.contributor.authorLee, J-
dc.contributor.authorKoh, HJ-
dc.contributor.authorMo, JH-
dc.contributor.authorJoo, YH-
dc.contributor.authorPark, YH-
dc.contributor.authorKim, HD-
dc.date.available2021-02-22T16:02:58Z-
dc.date.issued2004-04-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15888-
dc.description.abstractA series of chain-branched 1,3-dibenzylthiourea derivatives were synthesized, and tested their antagonist activity against vanilloid receptor 1. Chain-branching led to a significant change in the mode of action and the potency. (R)-Methyl or ethyl-branched 1,3-dibenzylthiourea derivatives showed the most potent antagonist activity up to the IC50 value of 0.05 muM which is 10-fold more potent than capsazepine. (C) 2004 Elsevier Ltd. All rights reserved.-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleChain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2004.01.066-
dc.identifier.scopusid2-s2.0-12144289391-
dc.identifier.wosid000220411200030-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.14, no.7, pp 1751 - 1755-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume14-
dc.citation.number7-
dc.citation.startPage1751-
dc.citation.endPage1755-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusHIGH-AFFINITY ANTAGONISTS-
dc.subject.keywordPlusANALGESIC PROPERTIES-
dc.subject.keywordPlusCAPSAICIN-
dc.subject.keywordPlusTETRAHYDROPYRAZINE-1(2H)-CARBOX-AMIDE(BCTC)-
dc.subject.keywordPlusRESINIFERATOXIN-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordPlusPOTENT-
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