Tetrazolo[1,5-a]quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents
DC Field | Value | Language |
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dc.contributor.author | Bekhit, AA | - |
dc.contributor.author | El-Sayed, AA | - |
dc.contributor.author | Aboulmagd, E | - |
dc.contributor.author | Park, JY | - |
dc.date.available | 2021-02-22T16:03:09Z | - |
dc.date.issued | 2004-03 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.issn | 1768-3254 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15902 | - |
dc.description.abstract | Three series of tetrazolo[ 1,5-alpha]quinoline derivatives have been synthesized. The first series was synthesized starting by the condensation of tetrazolo[1,5-alpha]quinoline-4-carboxaldehyde 2 with substituted thiosemicarbazides, followed by cyclization of the resulting thiosemicarba-zones 3 with malonic acid in the presence of acetyl chloride to give pyrimidyl derivatives 4a-c. The second series was prepared by the condensation of the latter compounds 4a-c with the selected aromatic aldehydes to afford the arylidene derivatives 5a-f. The third series 7a-c was synthesized by condensation of tetrazolo[1,5-a]quinoline-4-carboxaldehyde 2 with the appropriate acetophenone, followed by cyclocon-densation of the formed alpha,beta-unsaturated ketones with thiourea. The newly synthesized compounds were evaluated for their anti-inflammatory and antimicrobial activities. Four compounds were proved to be as active as indomethacin in animal models of inflammation. (C) 2003 Elsevier SAS. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.title | Tetrazolo[1,5-a]quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents | - |
dc.type | Article | - |
dc.publisher.location | 프랑스 | - |
dc.identifier.doi | 10.1016/j.ejmech.2003.12.005 | - |
dc.identifier.scopusid | 2-s2.0-1642409766 | - |
dc.identifier.wosid | 000221067100006 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.39, no.3, pp 249 - 255 | - |
dc.citation.title | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 249 | - |
dc.citation.endPage | 255 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | INFLAMMATORY-ANTIMICROBIAL AGENTS | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | ACIDS | - |
dc.subject.keywordAuthor | tetrazolo[ 1.5-a]quinoline | - |
dc.subject.keywordAuthor | pyrimidyl | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | antimicrobial | - |
dc.subject.keywordAuthor | ulcerogenic | - |
dc.subject.keywordAuthor | acute toxicity | - |
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