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N-4-substituted-benzyl-N '-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity

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dc.contributor.authorPark, H-
dc.contributor.authorChoi, JY-
dc.contributor.authorChoi, SH-
dc.contributor.authorPark, M-
dc.contributor.authorLee, J-
dc.contributor.authorSuh, YG-
dc.contributor.authorCho, HW-
dc.contributor.authorOh, UT-
dc.contributor.authorLee, JY-
dc.contributor.authorKang, SU-
dc.contributor.authorLee, J-
dc.contributor.authorKim, HD-
dc.contributor.authorPark, YH-
dc.contributor.authorJeong, YS-
dc.contributor.authorChoi, JK-
dc.contributor.authorJew, S-
dc.date.available2021-02-22T16:03:11Z-
dc.date.issued2004-02-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15904-
dc.description.abstractA series of N-4-substituted-benzyl-N'-tert-butylbenzyl thioureas were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor in rat DRG neurons. Their structure-activity relationship reveals that not only the two oxygens and amide hydrogen of sulfonamido group, but also the optimal size of methyl in methanesulfonamido group play an integral role for the antagonistic activity on vanilloid receptor. (C) 2003 Elsevier Ltd. All rights reserved.-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleN-4-substituted-benzyl-N '-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2003.11.019-
dc.identifier.scopusid2-s2.0-1542535807-
dc.identifier.wosid000188611500046-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.14, no.3, pp 787 - 791-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume14-
dc.citation.number3-
dc.citation.startPage787-
dc.citation.endPage791-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusHIGH-AFFINITY ANTAGONISTS-
dc.subject.keywordPlusANALGESIC AGENTS-
dc.subject.keywordPlusAGONIST ACTIVITY-
dc.subject.keywordPlusCAPSAICIN RECEPTOR-
dc.subject.keywordPlusTAIL INVITRO-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordPlusRESINIFERATOXIN-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusREGION-
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