폴리페놀의 비타민 C 안정성 유지와 피부 침투성 증가에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강재승 | - |
dc.contributor.author | 조대호 | - |
dc.contributor.author | 이왕재 | - |
dc.date.available | 2021-02-22T16:03:24Z | - |
dc.date.issued | 2004-12 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.issn | 2092-6685 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15921 | - |
dc.description.abstract | Background: It is necessary for human beings to uptake vitamin C through diet or supplements. It is also well-known that vitamin C plays an important role in the prevention of scurvy, enhancement of collagen synthesis and anti-tumor immune response. In addition, there are several recent reports regarding the effective role of vitamin C on the regulation of allergic responses, such as atopic dermatitis and asthma. However, the effective therapeutic and preventive measures using vitamin C are not established yet, since vitamin C is seriously unstable in aqueous solution. Therefore, we have investigated the best way to maintain the stability of vitamin C. Methods: After we making a mixture of polyphenol (0.001, 0.01, 0.1%) and vitamin C (1 mM), the mixtures were placed at room temperature both with/without light protection. And then the concentration of ascorbic acid was measured with HPLC. To analyze the in vivo effect of vitamin C on the regulation of skin allergic reaction, polyphenol (0.1%)-vitamin C (1 mM) mixture was applied to the skin and the production of histamine from mast cell was analyzed by Evans blue dye staining. Results: We have found that the polyphenol has preventive power of oxidation of vitamin C. In addition, the production of histamine was suppressed by the polyphenol (0.1%)-vitamin C (1 mM) mixture. Conclusion: We have reached the conclusion that our study suggests the research guideline for the therapy of atopic dermatitis through vitamin C. (Immune Network 2004;4(4): 250-254) | - |
dc.format.extent | 5 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한면역학회 | - |
dc.title | 폴리페놀의 비타민 C 안정성 유지와 피부 침투성 증가에 관한 연구 | - |
dc.title.alternative | Enhancement of the Stability and Skin Penetration of Vitamin C by Polyphenol. | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | Immune Network, v.4, no.4, pp 250 - 254 | - |
dc.citation.title | Immune Network | - |
dc.citation.volume | 4 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 250 | - |
dc.citation.endPage | 254 | - |
dc.identifier.kciid | ART001177203 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.subject.keywordAuthor | Vitamin C | - |
dc.subject.keywordAuthor | polyphenol | - |
dc.subject.keywordAuthor | histamine | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.subject.keywordAuthor | Vitamin C | - |
dc.subject.keywordAuthor | polyphenol | - |
dc.subject.keywordAuthor | histamine | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001177203 | - |
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