Effect of iontophoresis on the electrical properties of human skin in vivo
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seaung Y.Oh | - |
dc.contributor.author | Richard H.Guy | - |
dc.date.accessioned | 2023-12-18T10:02:31Z | - |
dc.date.available | 2023-12-18T10:02:31Z | - |
dc.date.issued | 1995-09 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.issn | 1873-3476 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159230 | - |
dc.description.abstract | Preliminary measurements have been made of the effect of iontophoresis on the electrical properties of human skin in vivo. Skin impedance was measured as a function of frequency and as a function of applied direct (i.e., iontophoretic) current. The resistance of the skin was then determined from the accumulated impedance data in the normal way. After the electrode chambers were attached to the forearm, and the pretreatment resistance had stabilized, direct current was applied and the % change from baseline resistance was determined. At the end of current passage, the recovery of resistance was monitored for up to 4 h. Current application involved three current densities applied for three different times (combined in such a way that three consistent amounts of total charge were delivered): 10 p,A/cm2 for 10, 20 and 50 min; 50μA/cm2 for 2, 4 and 10 min; and 100μA/cm2 for 1, 2 and 5 min. Current application caused skin resistance to drop rapidly (at all currents, most of the change occurs within 10 seconds of beginning the current flow). At all current levels, the decrease in skin resistance leveled off at a value which was dependent upon current density, but somewhat independent of time of current application: 10μA/cm2 -approx. 45% of pretreatment value; 50 μA/cm2 -approx. 20% of pretreatment value; and 100 μA/cm2 - approx. 10% of pretreatment value. The time required for recovery of skin resistance increased with (a) increasing time of current application (at constant current density), and (b) increasing current density. It is concluded that measurements of skin impedance (and derived values of skin resistance) in vivo, in man, can therefore provide direct electrical evaluation of the effects of iontophoresis on the tissue. Such measurements, we believe, are of vital importance with respect to the long-term application of iontophoresis as a method of drug delivery. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Effect of iontophoresis on the electrical properties of human skin in vivo | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/0378-5173(95)00180-Q | - |
dc.identifier.scopusid | 2-s2.0-0029133547 | - |
dc.identifier.wosid | A1995RR67500016 | - |
dc.identifier.bibliographicCitation | International Journal of Pharmaceutics, v.124, no.1, pp 137 - 142 | - |
dc.citation.title | International Journal of Pharmaceutics | - |
dc.citation.volume | 124 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 137 | - |
dc.citation.endPage | 142 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/037851739500180Q | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.