Chaperone-like activities of alpha-synuclein:alpha-synuclein assists enzyme activities of esterases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안미선 | - |
dc.contributor.author | 김승범 | - |
dc.contributor.author | 강미라 | - |
dc.contributor.author | 유연우 | - |
dc.contributor.author | 김두헌 | - |
dc.date.accessioned | 2023-12-18T10:31:57Z | - |
dc.date.available | 2023-12-18T10:31:57Z | - |
dc.date.issued | 2006-08 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159248 | - |
dc.description.abstract | α-Synuclein, a major constituent of Lewy bodies (LBs), has been implicated to play a critical role in the pathogenesis of Parkinson’s disease (PD), although the physiological function of α-synuclein has not yet been known. Here we have shown that α-synuclein, which has no well-defined secondary or tertiary structure, can protect the enzyme activity of microbial esterases against stress conditions such as heat, pH, and organic solvents. In particular, the flexibility of α-synuclein and its C-terminal region seems to be important for complex formation, but the structural integrity of the C-terminal region may not be required for stabilization of enzyme activity. In addition, atomic force microscopy (AFM) and in vivo enzyme assays showed highly specific interactions of esterases with α-synuclein. Our results indicate that α-synuclein not only protects the enzyme activity of microbial esterases in vitro, but also can stabilize the active conformation of microbial esterases in vivo. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier | - |
dc.title | Chaperone-like activities of alpha-synuclein:alpha-synuclein assists enzyme activities of esterases | - |
dc.title.alternative | Chaperone-like activities of α-synuclein: α-Synuclein assists enzyme activities of esterases | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.05.213 | - |
dc.identifier.scopusid | 2-s2.0-33745375279 | - |
dc.identifier.wosid | 000239016600006 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, v.346, no.4, pp 1142 - 1149 | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.volume | 346 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1142 | - |
dc.citation.endPage | 1149 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X06012563?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.