A membranous form of ICAM-1 on exosomes efficiently blocks leukocyte adhesion to activated endothelial cells
DC Field | Value | Language |
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dc.contributor.author | 이환명 | - |
dc.contributor.author | 최은정 | - |
dc.contributor.author | 김지현 | - |
dc.contributor.author | 김두헌 | - |
dc.contributor.author | 김윤근 | - |
dc.contributor.author | 강철훈 | - |
dc.contributor.author | 고용송 | - |
dc.date.accessioned | 2023-12-19T00:31:23Z | - |
dc.date.available | 2023-12-19T00:31:23Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159392 | - |
dc.description.abstract | While intercellular adhesion molecule-1 (ICAM-1) is a transmembrane protein, two types of extracellular ICAM-1 have been detected in cell culture supernatants as well as in the serum: a soluble form of ICAM-1 (sICAM-1) and a membranous form of ICAM-1 (mICAM-1) associated with exosomes. Previous observations have demonstrated that sICAM-1 cannot exert potent immune modulatory activity due to its low affinity for leukocyte function-associated antigen-1 (LFA-1) or membrane attack complex-1. In this report, we initially observed that human cancer cells shed mICAM-1(+)-exosomes but were devoid of vascular cell adhesion molecule-1 and E-selectin. We demonstrate that mICAM-1 on exosomes retained its topology similar to that of cell surface ICAM-1, and could bind to leukocytes. In addition, we show that exosomal mICAM-1 exhibits potent anti-leukocyte adhesion activity to tumor necrosis factor-a-activated endothelial cells compared to that of sICAM-1. Taken together with previous findings, our results indicate that mICAM-1 on exosomes exhibits potent immune modulatory activity. (C) 2010 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press | - |
dc.title | A membranous form of ICAM-1 on exosomes efficiently blocks leukocyte adhesion to activated endothelial cells | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2010.05.094 | - |
dc.identifier.scopusid | 2-s2.0-77955496871 | - |
dc.identifier.wosid | 000279718900023 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, v.397, no.2, pp 251 - 256 | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.volume | 397 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 251 | - |
dc.citation.endPage | 256 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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