A fatty acid-rich fraction of an endolichenic fungus<i> Phoma</i> sp. suppresses immune checkpoint markers via AhR/ARNT and ESR1
DC Field | Value | Language |
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dc.contributor.author | Varli, Mücahit | - |
dc.contributor.author | Ngo, Men Thi | - |
dc.contributor.author | Kim, Seong-Min | - |
dc.contributor.author | Tas, Isa | - |
dc.contributor.author | Zhou, Rui | - |
dc.contributor.author | Gamage, Chathurika D. B. | - |
dc.contributor.author | Pulat, Sultan | - |
dc.contributor.author | Park, So-Yeon | - |
dc.contributor.author | Sesal, Nüzhet Cenk | - |
dc.contributor.author | Hur, Jae-Seoun | - |
dc.contributor.author | Bin Kang, Kyo | - |
dc.contributor.author | Kim, Hangun | - |
dc.date.accessioned | 2023-12-19T07:30:16Z | - |
dc.date.available | 2023-12-19T07:30:16Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 2405-8440 | - |
dc.identifier.issn | 2405-8440 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159500 | - |
dc.description.abstract | Lung cancer has the highest mortality rates worldwide. The disease is caused by environmental pollutants, smoking, and many other factors. Recent treatments include immunotherapeutics, which have shown some success; however, the search for new therapeutics is ongoing. Endolichenic fungi produce a whale of a lot of secondary metabolites, the therapeutic effects of which are being evaluated. Here, we used a crude extract and subfractions of the endolichenic fungus, Phoma sp. (EL006848), isolated from the Pseudevernia furfuracea. It was identified the fatty acid components, palmitic acid, stearic acid, and oleic acid, exist in subfractions E1 and E2. In addition, EL006848 and its fatty acids fractions suppressed benzo[a]pyrene (an AhR ligand)induced expression of PD-L1 to inhibit the activity of multiple immune checkpoints. E2 sub fraction, which had a higher fatty acid content than E1, downregulated expression of AhR/ARNT and several human transcription factors related to ESR1. Moreover, E2 showed a strong inhibitory effect on STAT3 expression and mild effect on NF-kB activity. These results suggest that fatty acids extracted from an endolichenic fungus can exert strong immunotherapeutic effects. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | CELL PRESS | - |
dc.title | A fatty acid-rich fraction of an endolichenic fungus<i> Phoma</i> sp. suppresses immune checkpoint markers via AhR/ARNT and ESR1 | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.heliyon.2023.e19185 | - |
dc.identifier.scopusid | 2-s2.0-85172701491 | - |
dc.identifier.wosid | 001067941000001 | - |
dc.identifier.bibliographicCitation | HELIYON, v.9, no.9 | - |
dc.citation.title | HELIYON | - |
dc.citation.volume | 9 | - |
dc.citation.number | 9 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | PD-L1 EXPRESSION | - |
dc.subject.keywordPlus | B7-H1 EXPRESSION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordAuthor | Aryl hydrocarbon receptor | - |
dc.subject.keywordAuthor | Estrogen receptor | - |
dc.subject.keywordAuthor | Programmed death ligand 1 | - |
dc.subject.keywordAuthor | Immune checkpoint markers | - |
dc.subject.keywordAuthor | Natural product | - |
dc.subject.keywordAuthor | Endolichenic fungi | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2405844023063934?via%3Dihub | - |
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