Novel targets of beta-TrCP cooperatively accelerate carbohydrate and fatty acid consumption
DC Field | Value | Language |
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dc.contributor.author | Joo, Hyun Jeong | - |
dc.contributor.author | D'Alessandro, Matthew | - |
dc.contributor.author | Oh, Gaeun | - |
dc.contributor.author | Han, Sora | - |
dc.contributor.author | Kim, Woo Jung | - |
dc.contributor.author | Chung, Ga Eun | - |
dc.contributor.author | Jang, Youjeong | - |
dc.contributor.author | Lee, Jung Bok | - |
dc.contributor.author | Lee, Choogon | - |
dc.contributor.author | Yang, Young | - |
dc.date.accessioned | 2024-04-09T01:30:21Z | - |
dc.date.available | 2024-04-09T01:30:21Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 0021-9541 | - |
dc.identifier.issn | 1097-4652 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159839 | - |
dc.description.abstract | Cellular energy is primarily produced from glucose and fat through glycolysis and fatty acid oxidation (FAO) followed by the tricarboxylic acid cycle in mitochondria; energy homeostasis is carefully maintained via numerous feedback pathways. In this report, we uncovered a new master regulator of carbohydrate and lipid metabolism. When ubiquitin E3 ligase beta-TrCP2 was inducibly knocked out in beta-TrCP1 knockout adult mice, the resulting double knockout mice (DKO) lost fat mass rapidly. Biochemical analyses of the tissues and cells from beta-TrCP2 KO and DKO mice revealed that glycolysis, FAO, and lipolysis were dramatically upregulated. The absence of beta-TrCP2 increased the protein stability of metabolic rate-limiting enzymes including 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3), adipose triglyceride lipase (ATGL), carnitine palmitoyltransferase 1A (CPT1A), and carnitine/ acylcarnitine translocase (CACT). Our data suggest that beta-TrCP is a potential regulator for total energy homeostasis by simultaneously controlling glucose and fatty acid metabolism and that targeting beta-TrCP could be an effective strategy to treat obesity and other metabolic disorders. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Novel targets of beta-TrCP cooperatively accelerate carbohydrate and fatty acid consumption | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/jcp.31095 | - |
dc.identifier.scopusid | 2-s2.0-85168163599 | - |
dc.identifier.wosid | 001049890200001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR PHYSIOLOGY, v.239, no.3 | - |
dc.citation.title | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.citation.volume | 239 | - |
dc.citation.number | 3 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE COP1 | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | SIRT1 | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | LIPIN-1 | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordAuthor | E3 ligase | - |
dc.subject.keywordAuthor | energy homeostasis | - |
dc.subject.keywordAuthor | metabolism | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | ubiquitination | - |
dc.subject.keywordAuthor | beta-TrCP | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/jcp.31095 | - |
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