ROS-mediated cytoplasmic localization of CARM1 induces mitochondrial fission through DRP1 methylation
DC Field | Value | Language |
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dc.contributor.author | Cho, Yena | - |
dc.contributor.author | Kim, Yong Kee | - |
dc.date.accessioned | 2024-07-23T08:01:25Z | - |
dc.date.available | 2024-07-23T08:01:25Z | - |
dc.date.issued | 2024-07 | - |
dc.identifier.issn | 2213-2317 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/160308 | - |
dc.description.abstract | The dynamic regulation of mitochondria through fission and fusion is essential for maintaining cellular homeostasis. In this study, we discovered a role of coactivator-associated arginine methyltransferase 1 (CARM1) in mitochondrial dynamics. CARM1 methylates specific residues (R403 and R634) on dynamin-related protein 1 (DRP1). Methylated DRP1 interacts with mitochondrial fission factor (Mff) and forms self-assembly on the outer mitochondrial membrane, thereby triggering fission, reducing oxygen consumption, and increasing reactive oxygen species (ROS) production. This sets in motion a feedback loop that facilitates the translocation of CARM1 from the nucleus to the cytoplasm, enhancing DRP1 methylation and ROS production through mitochondrial fragmentation. Consequently, ROS reinforces the CARM1-DRP1-ROS axis, resulting in cellular senescence. Depletion of CARM1 or DRP1 impedes cellular senescence by reducing ROS accumulation. The uncovering of the above-described mechanism fills a missing piece in the vicious cycle of ROS-induced senescence and contributes to a better understanding of the aging process. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER | - |
dc.title | ROS-mediated cytoplasmic localization of CARM1 induces mitochondrial fission through DRP1 methylation | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.redox.2024.103212 | - |
dc.identifier.scopusid | 2-s2.0-85194880321 | - |
dc.identifier.wosid | 001263224200001 | - |
dc.identifier.bibliographicCitation | REDOX BIOLOGY, v.73 | - |
dc.citation.title | REDOX BIOLOGY | - |
dc.citation.volume | 73 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | DYNAMIN-RELATED PROTEIN-1 | - |
dc.subject.keywordPlus | ARGININE METHYLATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | DNM1L | - |
dc.subject.keywordPlus | MFF | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordAuthor | CARM1 | - |
dc.subject.keywordAuthor | DRP1 | - |
dc.subject.keywordAuthor | Methylation | - |
dc.subject.keywordAuthor | Mitochondrial dynamics | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | Senescence | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2213231724001903?via%3Dihub | - |
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