Phosphodiesterase 저해제 Pentoxifylline이 파골세포분화에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김민혜 | - |
dc.contributor.author | 전윤나 | - |
dc.contributor.author | 임미정 | - |
dc.date.available | 2021-02-22T16:15:52Z | - |
dc.date.issued | 2004-06 | - |
dc.identifier.issn | 0377-9556 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16042 | - |
dc.description.abstract | Phosphodiesterases (PDEs) are enzymes that degrade intracellular cAMP. In the present study, pentoxifylline, a PDE inhibitor, induced osteoclast formation in co-cultures of mouse bone marrow cells and calvarial osteoblasts. To address the involvement of the osteoclast differentiation factor TNF-related activation-induced cytokine (TRANCE, identical to RANKL, ODF, and OPGL), mouse bone marrow cells and calvarial osteoblasts were co-cultured with pentoxifylline in the presence of OPG, a decoy receptor for TRANCE. The osteoclastogenic effect of pentoxifylline was completely blocked by addition of OPG, suggesting that TRANCE is involved in the osteoclast formation induced by pentoxifylline. Northern blot analysis revealed that pentoxifylline significantly induced TRANCE mRNA expression in calvarial osteoblasts. These results suggests that pentoxifylline regulates TRANCE expression in osteoblasts, which in turn controls osteoclast formation. | - |
dc.format.extent | 5 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한약학회 | - |
dc.title | Phosphodiesterase 저해제 Pentoxifylline이 파골세포분화에 미치는 영향 | - |
dc.title.alternative | Effect of Pentoxifylline, a Phosphodiesterase Inhibitor, on Osteoclast Formation | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | 약 학 회 지, v.48, no.3, pp 197 - 201 | - |
dc.citation.title | 약 학 회 지 | - |
dc.citation.volume | 48 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 197 | - |
dc.citation.endPage | 201 | - |
dc.identifier.kciid | ART000933170 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.identifier.url | http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010024014329 | - |
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