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Synthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor

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dc.contributor.authorPark, HG-
dc.contributor.authorPark, MK-
dc.contributor.authorChoi, JY-
dc.contributor.authorChoi, SH-
dc.contributor.authorLee, J-
dc.contributor.authorSuh, YG-
dc.contributor.authorOh, U-
dc.contributor.authorLee, J-
dc.contributor.authorKim, HD-
dc.contributor.authorPark, YH-
dc.contributor.authorJeong, YS-
dc.contributor.authorChoi, JK-
dc.contributor.authorJew, SS-
dc.date.available2021-02-22T16:18:02Z-
dc.date.issued2003-01-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16220-
dc.description.abstractFour pyrrolidine derivatives were prepared by the formation of a 5-membered ring based on capsazepine. Among them, the two carbon extended derivatives, 4a (IC50 = 55 muM) and 4b (IC50 = 3 muM), both showed different levels of antagonist activity against the vanilloid receptor in a Ca-45(2+)-influx assay. (C) 2002 Elsevier Science Ltd. All rights reserved.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleSynthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/S0960-894X(02)00887-9-
dc.identifier.scopusid2-s2.0-0037212436-
dc.identifier.wosid000180412900008-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.2, pp 197 - 200-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume13-
dc.citation.number2-
dc.citation.startPage197-
dc.citation.endPage200-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusANALGESIC AGENTS-
dc.subject.keywordPlusAGONIST ACTIVITY-
dc.subject.keywordPlusCAPSAICIN ANALOGS-
dc.subject.keywordPlusTAIL INVITRO-
dc.subject.keywordPlusREGION-
dc.subject.keywordPlusRAT-
dc.subject.keywordPlusFIBERS-
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