No association of the TGF-beta(1) gene polymorphisms with the renal progression in autosomal dominant polycystic kidney disease (ADPKD) patients
DC Field | Value | Language |
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dc.contributor.author | Lee, JG | - |
dc.contributor.author | Ahn, C | - |
dc.contributor.author | Yoon, SC | - |
dc.contributor.author | Park, JH | - |
dc.contributor.author | Eo, HS | - |
dc.contributor.author | No, JJ | - |
dc.contributor.author | Kim, KH | - |
dc.contributor.author | Lee, EJ | - |
dc.contributor.author | Hwang, YH | - |
dc.contributor.author | Hwang, DY | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Han, JS | - |
dc.contributor.author | Kim, S | - |
dc.contributor.author | Lee, JS | - |
dc.contributor.author | Kim, SH | - |
dc.date.available | 2021-02-22T16:18:06Z | - |
dc.date.issued | 2003-01 | - |
dc.identifier.issn | 0301-0430 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16225 | - |
dc.description.abstract | Background: Two genetic loci, PKD1 and PKD2, have been identified as being responsible for ADPKD, and PKD1 is known to be associated with a poor prognosis. However, the presence of an intrafamilial study clinical diversity suggests that there are disease-modifying loci. Because the mechanism of the renal failure in ADPKD includes a cystic growth and tubulointerstitial atrophy and fibrosis, we studied the associations between 2 polymorphisms in the TGF-beta(1) gene, which are known to be associated with chronic tubulointerstitial inflammation, and ADPKD progression in Korean patients. Patients and methods: One hundred and twenty-five individuals who had ADPKD and 47 normal control subjects were genotyped by PCR-RFLP, the T869C (Leu10Pro) variant of TGF-beta(1) gene leader sequence was discriminated with MspA1I and the G915C (Arg25Pro) variants with BglI. Statistical significances were determined using the Chi-square test. Results: The distribution of the alleles for the TGFbeta(1) Leu10Pro polymorphism in ADPKD was: T 54%, C 46%, which was similar to the Korean (56:44, p=0.887) and Western controls (65:35). In addition, no differences were found between the ESRD and the non-ESRD groups (p=0.888) or the early hypertension and the normotension groups (p=0.249). The distribution of alleles for the TGFbeta(1) Arg25Pro polymorphism showed only the GG type which was different from the Western population controls (G:C=90:10, p=0.000). Conclusions: Our results suggest that the polymorphism at Arg25Pro of TGF-beta(1) in the Korean population has an allele distribution different from that of the Western population and that the polymorphism at Leu10Pro of TGF-beta(1) has no association with the renal progression in Korean ADPKD patients. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | DUSTRI-VERLAG DR KARL FEISTLE | - |
dc.title | No association of the TGF-beta(1) gene polymorphisms with the renal progression in autosomal dominant polycystic kidney disease (ADPKD) patients | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.5414/CNP59010 | - |
dc.identifier.scopusid | 2-s2.0-0037246033 | - |
dc.identifier.wosid | 000180114300002 | - |
dc.identifier.bibliographicCitation | CLINICAL NEPHROLOGY, v.59, no.1, pp 10 - 16 | - |
dc.citation.title | CLINICAL NEPHROLOGY | - |
dc.citation.volume | 59 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 10 | - |
dc.citation.endPage | 16 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | TRANSFORMING GROWTH-FACTOR-BETA-1 GENE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | JAPANESE | - |
dc.subject.keywordPlus | LINKAGE | - |
dc.subject.keywordPlus | TYPE-1 | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | PKD1 | - |
dc.subject.keywordAuthor | autosomal dominant | - |
dc.subject.keywordAuthor | polycystic kidney disease (ADPKD) | - |
dc.subject.keywordAuthor | TGF-beta 1 gene | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | Korean study | - |
dc.identifier.url | https://www.dustri.com/article_response_page.html?artId=252&doi=10.5414/CNP59010&L=0 | - |
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