Optimal Sampling Times of Once Daily Gentamicin in Korean Patients with Urinary Tract Infections
DC Field | Value | Language |
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dc.contributor.author | HyoJungPARK | - |
dc.contributor.author | KieHoSOHN | - |
dc.contributor.author | KyungEobCHOI | - |
dc.contributor.author | SangYupSHIN | - |
dc.contributor.author | SookInJUNG | - |
dc.contributor.author | WonSupOH | - |
dc.contributor.author | KyongRanPECK | - |
dc.contributor.author | JaeHoonSONG | - |
dc.contributor.author | SukHyangLEE | - |
dc.date.available | 2021-02-22T16:18:12Z | - |
dc.date.issued | 2003-09 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.issn | 2005-4483 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16234 | - |
dc.description.abstract | The clinical use of once daily aminoglycoside (ODA) dosing has been increased because of the poten-tial therapeutic advantages of this dosing regimen. To evaluate the optimal sampling times of ODA dosing methodin a clinical setting, the study was prospectively conducted in a total of 28 patients with UTI. All of the patientswere intravenously administered gentamicin at a dose of 7 mg/kg over 60 minutes and randomly divided into twogroups. Blood was collected at 0, 2, and 6 hours in Group A and at 1, 2, and 6 hours in Group B after the end of 1-hour infusion. The pharmacokinetic parameters (Ke, Vd and Cmax) obtained using the 0, 6 hour levels and 2, 6hour levels in Group A were statistically different while those of 1, 6 hour levels and 2, 6 hour levels in Group Bwere similar. This finding indicated that the distributional phase of ODA is completed within 1 hour following theend of the 1-hour infusion. If we are allowed to collect only two blood samples in ODA considering patients com-fort and the analytical cost of drug, the first one should be drawn after 1 hour following the end of infusion toobtain adequate pharmacokinetic information.Keywords□ once daily gentamicin, optimal sampling times, pharmacokinetic parameter | - |
dc.format.extent | 5 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 한국응용약물학회 | - |
dc.title | Optimal Sampling Times of Once Daily Gentamicin in Korean Patients with Urinary Tract Infections | - |
dc.title.alternative | Optimal Sampling Times of Once Daily Gentamicin in Korean Patients with Urinary Tract Infections | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | Biomolecules & Therapeutics, v.11, no.3, pp 178 - 182 | - |
dc.citation.title | Biomolecules & Therapeutics | - |
dc.citation.volume | 11 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 178 | - |
dc.citation.endPage | 182 | - |
dc.identifier.kciid | ART001197661 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.identifier.url | https://kiss.kstudy.com/Detail/Ar?key=2357850 | - |
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