Regulation of the manganese-containing superoxide dismutase gene from fission yeast
DC Field | Value | Language |
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dc.contributor.author | Jung, HI | - |
dc.contributor.author | Lee, YY | - |
dc.contributor.author | Lim, HW | - |
dc.contributor.author | Ahn, KS | - |
dc.contributor.author | Park, EH | - |
dc.contributor.author | Lim, CJ | - |
dc.date.available | 2021-02-22T16:31:25Z | - |
dc.date.issued | 2002-10 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16385 | - |
dc.description.abstract | The manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that dismutates a potentially toxic superoxide radical into hydrogen peroxide and dioxygen. To study the regulation of the Schizosaccharomyces pombe MnSOD gene, the 943 bp upstream region was fused into the promoterless beta-galactosidase gene of the shuttle vector YEp357, which resulted in the fusion plasmid pMS14. Restriction mapping and nucleotide sequencing confirmed its construction. The synthesis of beta-galactosidase from the fusion plasmid was induced by aluminum chloride, menadione, cadmium chloride, manganese chloride, and hydrogen peroxide. It was also induced by NO-generating S-nitroso-N-acetylpenicillamine (SNAP). However, cupric chloride and zinc chloride did not affect the synthesis of beta-galactosidase from the fusion plasmid. The beta-galactosidase synthesis appeared to be independent of the Pap1 protein. These results suggest that some metals, oxidative stress, and nitric oxide regulate the S. pombe MnSOD gene. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Regulation of the manganese-containing superoxide dismutase gene from fission yeast | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.scopusid | 2-s2.0-0037206537 | - |
dc.identifier.wosid | 000178998400020 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.14, no.2, pp 300 - 304 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 14 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 300 | - |
dc.citation.endPage | 304 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001189097 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | MNSOD GENE | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | CATALASE | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordAuthor | fission yeast | - |
dc.subject.keywordAuthor | MnSOD | - |
dc.subject.keywordAuthor | Schizosaccharomyces pombe | - |
dc.subject.keywordAuthor | superoxide dismutase | - |
dc.subject.keywordAuthor | transcriptional regulation | - |
dc.identifier.url | https://www.molcells.org/journal/view.html?pn=search&uid=901&vmd=Full | - |
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