Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid
DC Field | Value | Language |
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dc.contributor.author | Kang, BY | - |
dc.contributor.author | Chung, SW | - |
dc.contributor.author | Cho, D | - |
dc.contributor.author | Kim, TS | - |
dc.date.available | 2021-02-22T16:31:50Z | - |
dc.date.issued | 2002-05 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.issn | 1873-2968 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16414 | - |
dc.description.abstract | Interleukin (IL)-12 plays a pivotal role in the development of T helper type 1 (Th1)-immune response, which may have therapeutic effects on diseases associated with pathologic Th2 responses such as allergic disorders and asthma. In this study, we investigated the effects of berberine, a benzodioxoloquinolizine alkaloid with anti-microbial and anti-tumor activities, on the production of IL-12 p40, an inducible subunit of IL-12, in mouse macrophages. Berberine-induced IL-12 p40 production and activation of p38 mitogen-activated protein kinase (MAPK) in dose-dependent manners, which were significantly inhibited by p38 MAPK inhibitors and yohimbine, indicating that p38 MAPK and alpha(2)-adrenergic receptor were involved in the induction of IL-12 p40 production in mouse macrophages by berberine. Furthermore, berberine significantly enhanced IL-12 p40 production in mouse macrophages when combined with lipopolysaccharide, a well-known inducer of IL-12 production. These findings may explain some of the known biological effects of berberine and suggests berberine as an immunotherapeutic compound for induction of IL-12, which is potentially applicable for tumors, infectious disease, and airway inflammation. (C) 2002 Elsevier Science Inc. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/S0006-2952(02)00982-6 | - |
dc.identifier.scopusid | 2-s2.0-0037094342 | - |
dc.identifier.wosid | 000176577300014 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, v.63, no.10, pp 1901 - 1910 | - |
dc.citation.title | BIOCHEMICAL PHARMACOLOGY | - |
dc.citation.volume | 63 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1901 | - |
dc.citation.endPage | 1910 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INDUCED AIRWAY HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | CD40-INDUCED GENE-EXPRESSION | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | IFN-GAMMA PRODUCTION | - |
dc.subject.keywordPlus | IL-12 PRODUCTION | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | LEISHMANIA-MAJOR | - |
dc.subject.keywordAuthor | berberine | - |
dc.subject.keywordAuthor | interleukin-12 | - |
dc.subject.keywordAuthor | p38 MAPK | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
dc.subject.keywordAuthor | T helper | - |
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