Enhanced IL-18 expression in common skin tumors
DC Field | Value | Language |
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dc.contributor.author | Park, H | - |
dc.contributor.author | Byun, D | - |
dc.contributor.author | Kim, TS | - |
dc.contributor.author | Kim, YI | - |
dc.contributor.author | Kang, JS | - |
dc.contributor.author | Hahm, ES | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Lee, WJ | - |
dc.contributor.author | Song, HK | - |
dc.contributor.author | Yoon, DY | - |
dc.contributor.author | Kang, CJ | - |
dc.contributor.author | Lee, C | - |
dc.contributor.author | Houh, D | - |
dc.contributor.author | Kim, H | - |
dc.contributor.author | Cho, B | - |
dc.contributor.author | Kim, Y | - |
dc.contributor.author | Yang, YH | - |
dc.contributor.author | Min, KH | - |
dc.contributor.author | Cho, DH | - |
dc.date.available | 2021-02-22T16:34:06Z | - |
dc.date.issued | 2001-12 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.issn | 1879-0542 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16626 | - |
dc.description.abstract | Interleukin-18 (IL-18) has been found to have multiple effects upon various cells involved in inflammatory response. Recently we reported that B16 murine melanoma cells are able to produce IL-18, which is involved in the regulation of intracellular reactive oxygen intermediates (ROI) and Fas-ligand expression, indicating that IL-18 plays key role in the tumor activity of melanoma. In this study, we investigated the pattern of IL-18 expression in the human system. IL-18 production was tested by enzyme linked immunosorbent assay (ELISA) assay in various tumor cell lines, including Raji (Burkett's lymphoma), IM-9 (B lymphoblast), Jurkat (acute T cell leukemia), SK-MES-1 (squamous cell carcinoma (SCC) cell line), SK-MEL-2, G-361, DM-4, and DX-3 (melanoma cell lines). ELISA tests showed that IL-18 was highly expressed in malignant skin tumors such as SK-MES-1, SK-MEL-2, G-361, DM-4, and DX-3 cell lines, thus suggesting that IL-18 production may be associated with the malignancy of skin tumors. Here, we report that enhanced IL-18 expression is positively correlated with malignant skin tumors such as SCC and melanoma, suggesting the importance role of IL-18 in malignancy of skin tumors. Taken together, expression of IL-18 by tumor cells in human skin tissue may provide an important clue to understand the pathogenesis of malignant skin tumors. (C) 2001 Elsevier Science B.V. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Enhanced IL-18 expression in common skin tumors | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/S0165-2478(01)00278-4 | - |
dc.identifier.scopusid | 2-s2.0-0035802928 | - |
dc.identifier.wosid | 000172568000009 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY LETTERS, v.79, no.3, pp 215 - 219 | - |
dc.citation.title | IMMUNOLOGY LETTERS | - |
dc.citation.volume | 79 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 215 | - |
dc.citation.endPage | 219 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | GAMMA-INDUCING FACTOR | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | FAS LIGAND | - |
dc.subject.keywordPlus | MURINE MELANOMA | - |
dc.subject.keywordPlus | INTERLEUKIN-18 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INTERFERON | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordAuthor | IL-18 | - |
dc.subject.keywordAuthor | skin tumors | - |
dc.subject.keywordAuthor | squamous cell carcinoma | - |
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