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Synthesis of 5-azacytidine nucleosides with rigid sugar moiety as potential antitumor agents
- Issue Date
- Oct-2003
- Publisher
- MARCEL DEKKER INC
- Keywords
- 5-azacytidine; conformationally locked nucleosides
- Citation
- NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.22, no.5-8, pp 915 - 917
- Pages
- 3
- Journal Title
- NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- Volume
- 22
- Number
- 5-8
- Start Page
- 915
- End Page
- 917
- ISSN
- 1525-7770
- Abstract
- The bicyclic 3'-O,5'-C-methylene-linked and 2'-O,5'-C-methylene-linked 5-azacytidine derivatives were readily synthesized from 1,2;5,6-di-O-isopropylidene-D-glucose and evaluated against several cancer cell lines.
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