Canadine from Corydalis turtschaninovii Stimulates Myoblast Differentiation and Protects against Myotube Atrophy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyejin | - |
dc.contributor.author | Lee, Sang-Jin | - |
dc.contributor.author | Bae, Gyu-Un | - |
dc.contributor.author | Baek, Nam-In | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.date.available | 2021-02-22T05:32:51Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2190 | - |
dc.description.abstract | Cachexia and sarcopenia are the main causes of muscle atrophy. These result in a reduction in the muscle fiber area, myo-protein content, and muscle strength, with various molecular modulators being involved. Although several reports have proposed potential therapeutic agents, no effective treatments have been found for muscle atrophy. We searched for myogenic modulators from medicinal plants to treat muscle diseases. We isolated six alkaloids from Corydalis turtschaninovii and evaluated their myogenic potential by using the MyoD reporter gene assay in C2C12 cells. Among the tested compounds, canadine showed the strongest transactivation of MyoD and increased MHC expression during myogenesis. The activation of p38 MAP kinase and Akt are major mechanisms that contribute to the myogenesis by canadine. Canadine increased the number of multinucleated and cylinder-shaped myotubes during myogenesis of C2C12 myoblasts. To determine the preventive effect of canadine in cancer-induced muscle wasting, differentiated C2C12 myotubes were treated with conditioned media from CT26 colon carcinoma culture (CT26 CM) in the presence of canadine. Canadine ameliorated the muscle protein degradation caused by CT26-CM by down-regulating the muscle specific-E3 ligases, MAFbx/atrogin-1 and MuRF1. In this study, we found that canadine from C. turtschaninovii stimulates myogenesis and also inhibits muscle protein degradation. Therefore, we suggest canadine as a protective agent against muscle atrophy. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Canadine from Corydalis turtschaninovii Stimulates Myoblast Differentiation and Protects against Myotube Atrophy | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms18122748 | - |
dc.identifier.scopusid | 2-s2.0-85038419357 | - |
dc.identifier.wosid | 000418896700248 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.18, no.12 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 18 | - |
dc.citation.number | 12 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE ATROPHY | - |
dc.subject.keywordPlus | HYDRASTIS-CANADENSIS L. | - |
dc.subject.keywordPlus | SCUTELLARIA-BAICALENSIS | - |
dc.subject.keywordPlus | ISOQUINOLINE ALKALOIDS | - |
dc.subject.keywordPlus | CANCER CACHEXIA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | P38 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | BERBERINE | - |
dc.subject.keywordPlus | RHIZOMA | - |
dc.subject.keywordAuthor | Corydalis turtschaninovii | - |
dc.subject.keywordAuthor | isoquinoline alkaloid | - |
dc.subject.keywordAuthor | canadine | - |
dc.subject.keywordAuthor | myoblast differentiation | - |
dc.subject.keywordAuthor | muscle atrophy | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/18/12/2748 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.