Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growth
DC Field | Value | Language |
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dc.contributor.author | Go, Ga-Yeon | - |
dc.contributor.author | Lee, Sang-Jin | - |
dc.contributor.author | Jo, Ayoung | - |
dc.contributor.author | Lee, Jaecheol | - |
dc.contributor.author | Seo, Dong-Wan | - |
dc.contributor.author | Kang, Jong-Sun | - |
dc.contributor.author | Kim, Si-Kwan | - |
dc.contributor.author | Kim, Su-Nam | - |
dc.contributor.author | Kim, Yong Kee | - |
dc.contributor.author | Bae, Gyu-Un | - |
dc.date.available | 2021-02-22T05:33:25Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.issn | 2093-4947 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2235 | - |
dc.description.abstract | Background: Ginsenoside Rg1 belongs to protopanaxatriol-type ginsenosides and has diverse pharmacological activities. In this report, we investigated whether Rg1 could upregulate muscular stem cell differentiation and muscle growth. Methods: C2C12 myoblasts, MyoD-transfected 10T1/2 embryonic fibroblasts, and HEK293T cells were treated with Rg1 and differentiated for 2 d, subjected to immunoblotting, immunocytochemistry, or immunoprecipitation. Results: Rg1 activated promyogenic kinases, p38MAPK (mitogen-activated protein kinase) and Akt signaling, that in turn promote the heterodimerization with MyoD and E proteins, resulting in enhancing myogenic differentiation. Through the activation of Akt/mammalian target of rapamycin pathway, Rg1 induced myotube growth and prevented dexamethasone-induced myotube atrophy. Furthermore, Rg1 increased MyoD-dependent myogenic conversion of fibroblast. Conclusion: Rg1 upregulates promyogenic kinases, especially Akt, resulting in improvement of myoblast differentiation and myotube growth. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC GINSENG | - |
dc.title | Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growth | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1016/j.jgr.2017.05.006 | - |
dc.identifier.scopusid | 2-s2.0-85021741713 | - |
dc.identifier.wosid | 000413583900024 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GINSENG RESEARCH, v.41, no.4, pp 608 - 614 | - |
dc.citation.title | JOURNAL OF GINSENG RESEARCH | - |
dc.citation.volume | 41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 608 | - |
dc.citation.endPage | 614 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002274318 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE DIFFERENTIATION | - |
dc.subject.keywordPlus | FOXO TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | HYPERTROPHY | - |
dc.subject.keywordPlus | MYOGENESIS | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | CDO | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | ginsenoside Rg1 | - |
dc.subject.keywordAuthor | myoblast differentiation | - |
dc.subject.keywordAuthor | myogenic conversion | - |
dc.subject.keywordAuthor | myotube hypertrophy | - |
dc.subject.keywordAuthor | promyogenic signaling | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1226845317301276?via%3Dihub | - |
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