Unique Triterpenoid of Jujube Root Protects Cisplatin-induced Damage in Kidney Epithelial LLC-PK1 Cells via Autophagy Regulation
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Kang, Kyo Bin | - |
dc.contributor.author | Kim, Hyun Woo | - |
dc.contributor.author | Park, Jung Sik | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Choi, Sungyoul | - |
dc.contributor.author | Yamabe, Noriko | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.available | 2021-02-22T05:35:36Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2499 | - |
dc.description.abstract | Chronic exposure to cisplatin is associated with irreversible kidney impairment. In this present study, we explored the protective effects of 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME) isolated from roots of jujube (Ziziphus jujuba, Rhamnaceae) against cisplatin-induced damage in vitro. In kidney epithelial LLC-PK1 cells, western blotting and staining with specific autophagy epifluorescent dye CytoID were used to determine the molecular pathways involving autophagy. Treatment with 3DC2ME reduced the increased Cyto-ID-stained autophagic vesicles and reversed the protein expressions of 5' AMP-activated protein kinase subunit beta-1 (AMPK)/mammalian target of rapamycin (mTOR)-dependent signaling pathway in cisplatin-induced cell death. Additionally, treatment with autophagy inhibitor 3-methyladenine (3-MA) and with or without 3DC2ME attenuated the cisplatin-induced apoptosis. Although further research is necessary to substantiate the effects, we evaluated the potential mechanism of action of 3DC2ME as an adjuvant for cancer patients. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Unique Triterpenoid of Jujube Root Protects Cisplatin-induced Damage in Kidney Epithelial LLC-PK1 Cells via Autophagy Regulation | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/nu12030677 | - |
dc.identifier.scopusid | 2-s2.0-85081041270 | - |
dc.identifier.wosid | 000531831000086 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.12, no.3 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | NEPHROTOXICITY | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | LINE | - |
dc.subject.keywordAuthor | cisplatin | - |
dc.subject.keywordAuthor | nephrotoxicity | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | Ziziphus jujuba | - |
dc.identifier.url | https://www.mdpi.com/2072-6643/12/3/677 | - |
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