Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Targeted isolation of selaginellin derivatives using molecular networking strategy enhanced by in silico annotation

Full metadata record
DC Field Value Language
dc.contributor.authorWoo, S.-
dc.contributor.authorKang, K. B.-
dc.contributor.authorKim, J.-
dc.date.available2021-02-22T05:36:22Z-
dc.date.issued2019-12-
dc.identifier.issn0032-0943-
dc.identifier.issn1439-0221-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2704-
dc.description.abstractSelaginellins, unique pigments found in the genus Selaginella, were reported as potent phosphodiesterase-4 (PDE4) inhibitors in recent studies. To isolate diverse natural selaginellin derivatives, we applied a MS/MS based molecular networking strategy enhanced by in silico structural annotation to the Selaginella tamariscina extracts. It led to the prioritization of chromatographic peaks predicted as previously unknown selaginellin derivatives. As a result, we could isolate ten unknown compounds containing two unusual selaginellin analogs with 1H,3H-dibenzo[de,h]isochromene skeleton named selariscins A (1) and B (2) along with eight diarylfluorene derivatives, selaginpulvilins M−T (3−10). The absolute configurations were elucidated by computational electronic circular dichroism (ECD) spectral calculations. Some isolates showed PDE4 inhibitory activity with IC50 values in the range of 2.8−33.8 μM, and their binding modes were suggested using a molecular docking study.-
dc.format.extent1-
dc.language영어-
dc.language.isoENG-
dc.publisherGEORG THIEME VERLAG KG-
dc.titleTargeted isolation of selaginellin derivatives using molecular networking strategy enhanced by in silico annotation-
dc.typeArticle-
dc.publisher.location독일-
dc.identifier.doi10.1055/s-0039-3399844-
dc.identifier.wosid000503772900216-
dc.identifier.bibliographicCitationPLANTA MEDICA, v.85, no.18, pp 1467 - 1467-
dc.citation.titlePLANTA MEDICA-
dc.citation.volume85-
dc.citation.number18-
dc.citation.startPage1467-
dc.citation.endPage1467-
dc.type.docTypeMeeting Abstract-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaIntegrative & Complementary Medicine-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryIntegrative & Complementary Medicine-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.identifier.urlhttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-3399844-
Files in This Item
Go to Link
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kang, Kyo Bin photo

Kang, Kyo Bin
약학대학 (약학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE