Microfluidic Generation of Amino-Functionalized Hydrogel Microbeads Capable of On-Bead Bioassay
DC Field | Value | Language |
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dc.contributor.author | Kim, Seongsoo | - |
dc.contributor.author | Lee, Sang-Myung | - |
dc.contributor.author | Lee, Sung Sik | - |
dc.contributor.author | Shin, Dong-Sik | - |
dc.date.available | 2021-02-22T05:46:05Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 2072-666X | - |
dc.identifier.issn | 2072-666X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2910 | - |
dc.description.abstract | Microfluidic generation of hydrogel microbeads is a highly efficient and reproducible approach to create various functional hydrogel beads. Here, we report a method to prepare crosslinked amino-functionalized polyethylene glycol (PEG) microbeads using a microfluidic channel. The microbeads generated from a microfluidic device were evaluated by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and confocal laser scanning microscopy, respectively. We found that the microbeads were monodisperse and the amino groups were localized on the shell region of the microbeads. A swelling test exhibited compatibility with various solvents. A cell binding assay was successfully performed with RGD peptide-coupled amino-functionalized hydrogel microbeads. This strategy will enable the large production of the various functional microbeads, which can be used for solid phase peptide synthesis and on-bead bioassays. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Microfluidic Generation of Amino-Functionalized Hydrogel Microbeads Capable of On-Bead Bioassay | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/mi10080527 | - |
dc.identifier.scopusid | 2-s2.0-85071007410 | - |
dc.identifier.wosid | 000482989700002 | - |
dc.identifier.bibliographicCitation | MICROMACHINES, v.10, no.8 | - |
dc.citation.title | MICROMACHINES | - |
dc.citation.volume | 10 | - |
dc.citation.number | 8 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Instruments & Instrumentation | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Instruments & Instrumentation | - |
dc.subject.keywordPlus | PHASE PEPTIDE-SYNTHESIS | - |
dc.subject.keywordPlus | POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | SINGLE-MOLECULE | - |
dc.subject.keywordPlus | RESIN | - |
dc.subject.keywordPlus | PARTICLE | - |
dc.subject.keywordAuthor | polyethylene glycol | - |
dc.subject.keywordAuthor | hydrogel microbead | - |
dc.subject.keywordAuthor | microfluidic channel | - |
dc.subject.keywordAuthor | on-bead bioassay | - |
dc.subject.keywordAuthor | peptide synthesis | - |
dc.identifier.url | https://www.mdpi.com/2072-666X/10/8/527 | - |
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