Liposomal itraconazole formulation for the treatment of glioblastoma using inclusion complex with HP-β-CD
DC Field | Value | Language |
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dc.contributor.author | Yoon, Sung-Won | - |
dc.contributor.author | Shin, Dae Hwan | - |
dc.contributor.author | Kim, Jin-Seok | - |
dc.date.available | 2021-02-22T05:46:24Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 2093-5552 | - |
dc.identifier.issn | 2093-6214 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2957 | - |
dc.description.abstract | Purpose: Itraconazole, which has been widely used as an antifungal-agent, is revisited as an anticancer drug but its low solubility still remains a major hurdle. Methods: Inclusion complex was used to enhance the solubility of itraconazole, followed by encapsulating into liposome for glioblastoma. Results: Itraconazole-inclusion complex was well formed at 1:1, 1:2 and 1:3 molar ratios of itraconazole: hydroxypropyl-β-cyclodextrin (HP-β-CD) as determined by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and Fourier transform infrared spectroscopy (FT-IR) analyses. Itraconazole-HP-β-CD inclusion complex was then encapsulated in liposome and its size was 120.5 ± 53.1 nm in diameter with 50% encapsulation efficiency. Stem cell-like property, as determined by the population ratio of CD90+/CD133+, was decreased from 3.38 to 1.46% when the U87-MG-TL cells were treated with 100 µM itraconazole/HP-β-CD-loaded liposome. Anti-proliferative effect of itraconazole/HP-β-CD-loaded liposome on U87-MG-TL cells was slightly better than that of free itraconazole (IC50 of 17 µM vs. 26 µM). Moreover, anti-proliferative effect of Itraconazole/HP-β-CD-loaded liposome on U87-MG-TL cells was higher than that of free itraconazole when the cells were co-treated with temozolomide (IC50 of 1.58 mM vs. 2.35 mM). Conclusions: Therefore, itraconazole/HP-β-CD-loaded liposomal formulation could serve as a promising strategy for targeting the glioblastoma multiforme. © 2019, The Korean Society of Pharmaceutical Sciences and Technology. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Netherlands | - |
dc.title | Liposomal itraconazole formulation for the treatment of glioblastoma using inclusion complex with HP-β-CD | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s40005-019-00432-4 | - |
dc.identifier.scopusid | 2-s2.0-85071465689 | - |
dc.identifier.bibliographicCitation | Journal of Pharmaceutical Investigation, v.49, no.4, pp 477 - 483 | - |
dc.citation.title | Journal of Pharmaceutical Investigation | - |
dc.citation.volume | 49 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 477 | - |
dc.citation.endPage | 483 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002487902 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | 2 hydroxypropyl beta cyclodextrin | - |
dc.subject.keywordPlus | CD133 antigen | - |
dc.subject.keywordPlus | itraconazole | - |
dc.subject.keywordPlus | temozolomide | - |
dc.subject.keywordPlus | Thy 1 membrane glycoprotein | - |
dc.subject.keywordPlus | antineoplastic activity | - |
dc.subject.keywordPlus | antiproliferative activity | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | cell culture | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | differential scanning calorimetry | - |
dc.subject.keywordPlus | drug formulation | - |
dc.subject.keywordPlus | drug mixture | - |
dc.subject.keywordPlus | drug solubility | - |
dc.subject.keywordPlus | drug synthesis | - |
dc.subject.keywordPlus | encapsulation | - |
dc.subject.keywordPlus | flow cytometry | - |
dc.subject.keywordPlus | fluorescence activated cell sorting | - |
dc.subject.keywordPlus | Fourier transform infrared spectroscopy | - |
dc.subject.keywordPlus | glioblastoma | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human cell | - |
dc.subject.keywordPlus | IC50 | - |
dc.subject.keywordPlus | in vitro study | - |
dc.subject.keywordPlus | liposomal delivery | - |
dc.subject.keywordPlus | mathematical model | - |
dc.subject.keywordPlus | MTT assay | - |
dc.subject.keywordPlus | particle size | - |
dc.subject.keywordPlus | pore size distribution | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | U-87MG ATCC cell line | - |
dc.subject.keywordPlus | X ray diffraction | - |
dc.subject.keywordAuthor | Cyclodextrin | - |
dc.subject.keywordAuthor | Glioblastoma multiforme | - |
dc.subject.keywordAuthor | Inclusion complex | - |
dc.subject.keywordAuthor | Itraconazole | - |
dc.subject.keywordAuthor | Liposome | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs40005-019-00432-4 | - |
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