토끼에서 ACAT 억제에 의한 3,4-다이하이드록시 하이드로시나믹산의 동맥경화 완화 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이미란 | - |
dc.contributor.author | 최재훈 | - |
dc.contributor.author | 양영 | - |
dc.contributor.author | 오기숙 | - |
dc.contributor.author | 정태숙 | - |
dc.contributor.author | 이철호 | - |
dc.contributor.author | 오구택 | - |
dc.date.available | 2021-02-22T05:49:24Z | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1738-3544 | - |
dc.identifier.issn | 2288-1662 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3201 | - |
dc.description.abstract | Polyphenols have been reported to have beneficial effects on cardiovascular disease. A polyphenolic compound, 3,4-dihydroxy-hydrocinnamic acid (3,4-DHHCA), has been shown to have antioxidative and antitumorigenic activities. However, the effect of 3,4-DHHCA on atherosclerosis is still unknown. Herein, we investigated the effects of 3,4-DHHCA on atherosclerosis in New Zealand White rabbits. Broad and fused fatty streak lesions were found in rabbits fed with high-cholesterol diet for 8 weeks. Administration of 3,4-DHHCA reduced atherosclerotic lesion formation and lesional accum-ulation of macrophage in rabbits fed with cholesterol diet without systemic or local toxicity. Hepatic acyl-coenzyme A: cholesterol acyltransferase (ACAT) activity was decreased after treatment with 3,4-DHHCA by 22% in cholesterol diet-fed rabbits compared with the control group. These results indicate that 3,4-DHHCA had antiatherogenic effects in rabbits, possibly by partial inhibition of ACAT. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한임상검사과학회 | - |
dc.title | 토끼에서 ACAT 억제에 의한 3,4-다이하이드록시 하이드로시나믹산의 동맥경화 완화 효과 | - |
dc.title.alternative | Attenuation of Atherosclerosis by 3,4-Dihydroxy- Hydrocinnamic Acid in Rabbits by Partial Inhibition of ACAT | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.15324/kjcls.2016.48.4.280 | - |
dc.identifier.bibliographicCitation | 대한임상검사과학회지, v.48, no.4, pp 280 - 286 | - |
dc.citation.title | 대한임상검사과학회지 | - |
dc.citation.volume | 48 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 280 | - |
dc.citation.endPage | 286 | - |
dc.identifier.kciid | ART002173956 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | 3 | - |
dc.subject.keywordAuthor | 4-dihydroxy-hydrocinnamic acid | - |
dc.subject.keywordAuthor | Animal models | - |
dc.subject.keywordAuthor | Acyl-CoA:cholesterol acyltransferase | - |
dc.subject.keywordAuthor | High density lipoprotein | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=3487867 | - |
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