Prognostic and Clinicopathological Significance of SERTAD1 in Various Types of Cancer Risk: A Systematic Review and Retrospective Analysis
DC Field | Value | Language |
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dc.contributor.author | Mongre, Raj Kumar | - |
dc.contributor.author | Jung, Samil | - |
dc.contributor.author | Mishra, Chandra Bhushan | - |
dc.contributor.author | Lee, Beom Suk | - |
dc.contributor.author | Kumari, Shikha | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.date.available | 2021-02-22T06:45:51Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3758 | - |
dc.description.abstract | SERTAD/TRIP-Br genes are considered as a key nuclear transcriptional player in diverse mechanisms of cell including carcinogenesis. The Oncomine (TM)-Online Platform was used for differential expression and biological insights. Kaplan-Meier survival estimated by KM-plotter/cBioPortal/PrognoScan with 95% CI. SERTAD1 was found significantly elevated levels in most of tumor samples. Kaplan-Meier Plotter results distinctly showed the SERTAD1 over-expression significantly reduced median overall-survival (OS) of patients in liver (n = 364/Logrank-test p = 0.0015), ovarian (n = 655/Logrank-test p = 0.00011) and gastric (n = 631/Logrank-test p = 0.1866). Increased level of SERTAD1 has a significantly higher survival rate in the initial time period, but after 100 months slightly reduced OS (n = 26/Logrank-test p = 0.34) and RFS in HER2 positive breast cancer patients. In meta-analysis, cancer patients with higher SERTAD1 mRNA fold resulted worse overall survival than those with lower SERTAD1 levels. Heterogeneity was observed in the fixed effect model analysis DFS [Tau(2) = 0.0.073, Q (df = 4) = 15.536 (p = 0.004), I-2 = 74.253], DSS [Tau(2) = 1.015, Q (df = 2) = 33.214, (p = 0.000), I-2 = 93.973], RFS [Tau(2) = 0.492, Q (df = 7) = 71.133 (p = 0.000), I-2 = 90.159] (Figure 5). OS [Tau(2) = 0.480, Q (df = 17) = 222.344 (p = 0.000), I-2 = 92.354]. Lastly, SERTAD1 involved in several signaling cascades through interaction and correlation with many candidate factors as well as miRNAs. This meta-analysis demonstrates a robust evidence of an association between higher or lower SERTAD1, alteration and without alteration of SERTAD1 in cancers in terms of survival and cancer invasiveness. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Prognostic and Clinicopathological Significance of SERTAD1 in Various Types of Cancer Risk: A Systematic Review and Retrospective Analysis | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/cancers11030337 | - |
dc.identifier.scopusid | 2-s2.0-85064356111 | - |
dc.identifier.wosid | 000468550200067 | - |
dc.identifier.bibliographicCitation | CANCERS, v.11, no.3 | - |
dc.citation.title | CANCERS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 3 | - |
dc.type.docType | Review | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | TRIP-BR FAMILY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | GENOMIC INSTABILITY | - |
dc.subject.keywordPlus | MOLECULAR SUBTYPES | - |
dc.subject.keywordPlus | P34(SEI-1) | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | DATABASE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | SERTAD1 | - |
dc.subject.keywordAuthor | overall survival | - |
dc.subject.keywordAuthor | disease | - |
dc.subject.keywordAuthor | relapse free survival | - |
dc.subject.keywordAuthor | mutation | - |
dc.subject.keywordAuthor | correlation | - |
dc.subject.keywordAuthor | protein interaction | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | miRNAs | - |
dc.identifier.url | https://www.mdpi.com/2072-6694/11/3/337 | - |
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