의약품부작용보고시스템 데이터베이스를 이용한 고강도 statin과 중·저강도 statin 관련 이상사례 비교 분석
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이세라 | - |
dc.contributor.author | 옥미영 | - |
dc.contributor.author | 김현아 | - |
dc.date.available | 2021-02-22T07:46:05Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 1226-6051 | - |
dc.identifier.issn | 2508-786X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4084 | - |
dc.description.abstract | Background: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) effectively reduce serum levels of low-densitylipoprotein (LDL) and total cholesterol. High-intensity statins are recommended for all patients aged ≤75 with clinical atheroscleroticcardiovascular disease (ASCVD), diabetes mellitus aged 40-75 with ≥7.5% estimated 10-year ASCVD risk and LDL-C ≥190 mg/dL. High-intensity statins associated with more frequent adverse events (AEs) compared to moderate- to low-intensity statins. Theaim of this study was to compare AEs between high-intensity and moderate- to low-intensity statin group using the Korea AdverseEvent Reporting System (KAERS) database. Methods: Adults (≥18 years) with statin-associated AEs from July 2009-June 2014were included. Only AEs classified as “certain”, “probable” and “possible” based on the WHO-Uppsala Monitoring Center criteriawere analyzed. Results: In total, 247 AEs from 196 patients [high-intensity statin group (HG), n = 25 (13%); moderate- to lowintensitystatin group (MLG), n = 171 (87%)] were included. Mean age was higher in HG compared with MLG (67 ± 14 vs 62 ± 12). The HG showed a significant higher frequency of liver/biliary system disorders (37% vs 14%, p = 0.001). Hepatic function abnormalwas reported more frequently in HG compared to MLG (26% vs 9%, p = 0.006). Conclusion: According to KAERS data, liver/biliarysystem disorders were more frequently reported in HG compared to MLG. | - |
dc.format.extent | 7 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 한국임상약학회 | - |
dc.title | 의약품부작용보고시스템 데이터베이스를 이용한 고강도 statin과 중·저강도 statin 관련 이상사례 비교 분석 | - |
dc.title.alternative | Comparison of Adverse Events between High-intensity and Moderate- to Low-intensity Statin Group | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.24304/kjcp.2018.28.4.347 | - |
dc.identifier.bibliographicCitation | 한국임상약학회지, v.28, no.4, pp 293 - 299 | - |
dc.citation.title | 한국임상약학회지 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 293 | - |
dc.citation.endPage | 299 | - |
dc.identifier.kciid | ART002423590 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Hydroxymethylglutaryl-CoA reductase inhibitors | - |
dc.subject.keywordAuthor | KAERS | - |
dc.subject.keywordAuthor | drug-related side effects | - |
dc.subject.keywordAuthor | adverse reactions | - |
dc.identifier.url | http://www.ekjcp.org/journal/view.html?doi=10.24304/kjcp.2018.28.4.347 | - |
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